Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits  

作　　者：Song-tao LI Xiao-wei CHEN Hong-mei ZHAO Na LI Jie YAN Zhi-an HU 

机构地区：[1]Experimental Center of Basic Medicine [2]Department of Neurobiology, Third Military Medical University, Chongqing 400038, China

出　　处：《Acta Pharmacologica Sinica》2006年第2期212-216,共5页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(№30370465)

摘　　要：Aim： To investigate the effects of peripheral orexins on myoelectric activity of the sphincter of Oddi （SO） in fasted rabbits, and carry out a preliminary investigation into the mechanisms underlying these effects. Methods： Myoelectric activity of SO in fasted rabbits was recorded before and after intravenous or local application of orexins. The effects of intravenous atropine on orexin-increased myoelectric activity of SO were tested. Results： Myoelectric activity of SO was activated by both intravenous and local injection of orexin-A or orexin-B. Intravenous application of atropine completely inhibited the excitatory effect of orexins on SO. Conclusion： Peripheral application of orexins can increase myoelectric activity of SO in fasted rabbits, which is partially associated with the activation of the cholinergic pathway.Aim： To investigate the effects of peripheral orexins on myoelectric activity of the sphincter of Oddi （SO） in fasted rabbits, and carry out a preliminary investigation into the mechanisms underlying these effects. Methods： Myoelectric activity of SO in fasted rabbits was recorded before and after intravenous or local application of orexins. The effects of intravenous atropine on orexin-increased myoelectric activity of SO were tested. Results： Myoelectric activity of SO was activated by both intravenous and local injection of orexin-A or orexin-B. Intravenous application of atropine completely inhibited the excitatory effect of orexins on SO. Conclusion： Peripheral application of orexins can increase myoelectric activity of SO in fasted rabbits, which is partially associated with the activation of the cholinergic pathway.

关 键 词：sphincter of Oddi OREXINS myoelectricactivity spike potential RABBITS 

分 类 号：R337.5[医药卫生—人体生理学]