阿糖胞苷纳米粒冻干针剂家兔体内药物动力学研究  

The Pharmacokinetic Study on Cytarabine Nanoparticle Lyophilization Injection in Rabbits

作　　者：周静[1] 蒋学华[1] 何林[2] 李晨睿[1] 杨俊毅[1] 

机构地区：[1]四川大学华西药学院临床药学教研室,成都610041 [2]四川省人民医院药剂科

出　　处：《四川大学学报（医学版）》2006年第1期145-147,共3页Journal of Sichuan University(Medical Sciences)

摘　　要：目的研究阿糖胞苷聚氰基丙烯酸正丁酯纳米粒(ARA-C-PBCA-NP)冻干针剂在家兔体内的药物动力学规律。方法以阿糖胞苷(ARA-C)溶液剂为参比,采用HPLC法测定ARA-C-PBCA-NP冻干针剂和ARA-C溶液剂在家兔体内的血药浓度,计算药动学参数。结果ARA-C-PBCA-NP冻干针剂和ARA-C溶液剂在家兔体内的药物动力学过程均符合二室模型,ARA-C-PBCA-NP冻干针剂在家兔体内的T1/2Β和平均滞留时间(MRT)延长,清除率(CL)降低(P<0.05)。结论ARA-C-PBCA-NP冻干针剂可显著延长ARA-C在体内的存留时间,具有明显的缓释特征。Objective The pharmacokinetics of Cytarabine Polybutylcyanoacrylate Nanoparticles （Ara-C-PBCA-NP） lyophilization injection in rabbits was studied. Methods Ara-C water solution was taken as reference, the concentration of Ara-C was determined by HPLC, and the pharmaeokinetic parameters were calculated. Results Pharmaeokinetie properties of Ara-C water solution and Ara-C-PBCA-NP lyophilization injection complied with two-department model, The parameters t1/2β and MRT of Ara-C-PBCA-NP lyophilization injection were prolonged, and CL was reduced dramatieally（P〈0. 05）. Conclusion Ara-C-PBCA-NP lyophilization injection possesses prolonged retention time in vivo and significant sustained releasing character.

关 键 词：阿糖胞苷 纳米粒 药物动力学 

分 类 号：R96[医药卫生—药理学]