缓激肽预处理对大鼠局灶性脑缺血的影响  

Effects of bradykinin preconditioning on cerebral ischemia

作　　者：安平[1] 赵晓春[2] 王玉勤[1] 薛一雪[1] 

机构地区：[1]中国医科大学基础医学院神经生物学教研室,辽宁沈阳110001 [2]中国医科大学第二临床学院麻醉科,辽宁沈阳110003

出　　处：《中国药理学通报》2006年第1期27-30,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30070268;30070768;30400145)

摘　　要：目的研究缓激肽预处理对大鼠局灶性脑缺血/再灌注损伤的影响。方法线栓法制备大鼠大脑中动脉缺血/再灌注模型,在缺血前由颈外动脉泵入缓激肽,对照组给予等量生理盐水,缺血2 h再灌注24 h后,观察脑梗死体积、脑含水量、血脑屏障通透性及组织病理学的变化。结果缺血前15 m in给予缓激肽组与对照组相比,梗死体积减小、水肿程度减轻、血脑屏障通透性降低、相关脑区神经元损伤程度减轻。结论预先给予缓激肽可对脑缺血损伤起保护作用,这可能是通过保护脑血管、减少梗死体积来起作用的。Aim To investigate the effects of bradykinin preconditioning on the damage produced by focal cerebral ischemia-reperfusion in rats. Methods Rats were scheduled to undergo middle cerebral artery ischemia-reperfusion by intraluminal suture. Prior to ischemia, bradykinin was pumped into the brain via extra carotid artery and control group was given the same amount of normal saline. The infarct volume ,brain water content ,permeability of blood brain barrier and histological neuronal changes were evaluated after 2 h ischemia and 24 h reperfusion. Results Compared with other groups, bradykinin preconditioning 15rain before ischemia reduced infarct volume ,brain edema,permeability of blood brain barrier and histological neuronal damage. Conclusion Bradykinin preconditioning may provide protective effects against cerebral ischemic injury. This protection may be due to the protection of cerebral vasculature and the decrease of infarct volume.

关 键 词：缓激肽 脑缺血 脑水肿 血脑屏障 

分 类 号：R332[医药卫生—人体生理学] R322.81[医药卫生—基础医学]