麦考酚酸联合迪银片治疗寻常型银屑病的近期临床疗效观察  

Psoriasis Vulgaris Treated Successfully with DIYINPIAN Combined with Mycophenolate Mofetil

作　　者：朱晓浚[1] 叶小茵[2] 刘次伟[1] 

机构地区：[1]中山大学附属二院皮肤科,广东广州510120 [2]福建医科大学协和医院皮肤科,福建福州350001

出　　处：《中国皮肤性病学杂志》2006年第1期61-62,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的研究麦考酚酸(MMF)联合迪银片治疗寻常型银屑病的使用方法、近期临床疗效及其副作用。方法46例患者随机分为治疗组和对照组。治疗组23例,MMF1.5 g/d分3次口服,1月后,减为1.0 g 2次/d,共4周,同时服用迪银片5片,3次/d共8周;对照组32例,服用迪银片和火把花根各5片,均3次/d,共8周。结果治疗组基本痊愈14例,显效5例,进步2例,无效2例,有效率91.30%;对照组基本痊愈16例,显效8例,进步2例,无效6例,有效率81.25%。两组疗效差异无显著性(P>0.05)。结论MMF联合迪银片治疗寻常型银屑病疗效与迪银片联合火把花根片相当,有较好的疗效。但因其价格昂贵,可作为二线银屑病治疗药物。Objective To investigate the effective in the near future, administer and adverse reaction of treatment of psoriasis vulgarise with combined MMF. Methods In treatment group,23 patient with psoriasis vulgarise were treatmented with MMF （0.5 rid × 4w, thereafter,0.5 bid × 4w） combinting DIYINPIAN （5pills rid × 8w）, and in contol group 32 patient with psoriasis vulgarise were treatmented with DIYINPIAN （5pills tid × 8w）combinting HUOBAHUAGEN 5pills tid × 8w. The effectiveness between two groups after treatment was compared. Results In treatment group of 23patients, there were recovery 14 cases,good 5,ordinary 2,no-effective 2,and total rate of effectiveness was 91.30%. No significal differentiation （P 〉 0.05 ） was between two groups. Conclusion Protocol of MMF combinating DIYINPIAN has good effective in treatment of psoriasis vulgarise,which is equal to control group （ DIYINPIAN combinating HUOBAHUAGEN ） , and is elected only as the second line drug for its high price.

关 键 词：银屑病 寻常型 麦考酚酸 迪银片 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]