血脑屏障的基因组学和蛋白质组学研究进展  

Advances in the Studies on Blood-Brain Barrier Using Genomic and Proteomic Approaches

作　　者：顾勇[1] 张成岗[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京市100850

出　　处：《医学分子生物学杂志》2006年第1期36-39,共4页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展计划(973计划)(2003CB715900);国家高技术研究发展计划(863计划)(2002AA234021)~~

摘　　要：血脑屏障是分隔外周血和大脑的屏障,选择性地允许或阻止物质在两者间的通透。近年来陆续有研究指出,血脑屏障存在大量转运体参与重要生理物质选择性进入大脑,并且将代谢产物转运入血以维持脑内环境稳定。血脑屏障功能失调与很多脑疾病密切相关。基因组学与蛋白质组学等研究方法的介入可高通量、大规模地研究血脑屏障中的转运体,极大地加快了人们对血脑屏障在疾病发生发展中的作用以及临床治疗研究中的认识。Blood-brain barrier （BBB） is an impermeable cellular interface that separates the blood from the brain, selectively allows and inhibits the permeability of substances between them. Recent studies show that there are many transporters involved in the selective influx of important physical substances and efflux of the metabolic products to maintain the stability of the inner environment. In addition, BBB dysfunction has been observed in avarrety of neurological diseases. The genomics and proteomics technologies may reveal more about BBB transporters. It is evident that these approaches significantly advance our understanding of BBB function in the progression of diseases and the researches on the clinical treatment.

关 键 词：血脑屏障 基因组学 蛋白质组学 脑疾病 

分 类 号：Q42[生物学—神经生物学]