人类T淋巴细胞白血病病毒流行区无偿献血人群筛查研究  

Screening of Human T-lymphotropic Virus in Voluntary Blood Donors in an Endemic Area

作　　者：陈长荣 张军[2] 谢金镇 张永昌 王颖彬[2] 

机构地区：[1]厦门市中心血站,厦门361004 [2]厦门大学细胞生物学与肿瘤细胞工程教育部重点实验室,厦门361005

出　　处：《病毒学报》2006年第1期54-57,共4页Chinese Journal of Virology

摘　　要：In order to evaluate the blood screening of human T-lymphotropic virus(HTLV) infection in endemic regions in China,a total of 32 767 voluntary blood donors in Xiamen during February 2004 to February 2005 were tested for anti-HTLV Ⅰ/Ⅱ using an ELISA kit.Those repeatedly positive samples were further confirmed by Western blot and PCR.Thirteen donors were positive for antiHTLV by ELISA and 7 among them were confirmed by Western blot,while one was doubtful.HTLV I env gene fragments from four confirmed samples were amplified successfully by PCR.Phylogenetic analysis showed that they were all grouped into subtype C.None of the seven confirmed donors came from Xiamen City,but from other areas of Fujian Province.Five of these 7 donors came from the coastal area of Fujian Province,while the other two came from inland area.In order to evaluate the blood screening of human T-lymphotropic virus （HTLV） infection in endemic regions in China, a total of 32 767 voluntary blood donors in Xiamen during February 2004 to February 2005 were tested for anti- HTLV Ⅰ /Ⅱ using an ELISA kit. Those repeatedly positive samples were further confirmed by Western blot and PCR. Thirteen donors were positive for anti-HTLV by ELISA and 7 among them were confirmed by Western blot, while one was doubtful. HTLV Ⅰ env gene fragments from four confirmed samples were amplified successfully by PCR, Phylogenetic analysis showed that they were all grouped into subtype C. None of the seven confirmed donors came from Xiamen City, but from other areas of Fujian Province. Five of these 7 donors came from the coastal area of Fujian Province, while the other two came from inland area.

关 键 词：人类T淋巴细胞白血病病毒 筛查 无偿献血者 

分 类 号：R373.3[医药卫生—病原生物学]