通心络对自发性高血压大鼠阻力血管结构的影响  

Effects of Tongxinluo on Structure and funetion of Resistance Vessels in Spontaneously Hypertensive Rats

作　　者：王华军[1] 谢良地[1] 姚恩辉[1] 许昌声[1] 

机构地区：[1]福建医科大学附属第一医院高血压研究所,福建福州350005

出　　处：《高血压杂志》2006年第1期61-63,共3页Chinese Journal of Hypertension

基　　金：福建省教育厅基金资助项目;编号:JB04209

摘　　要：目的观察通心络对自发性高血压大鼠(SHR)的血压、阻力血管结构的影响。方法30只12周龄雄性SHR大鼠,随机分成3组:(1)大剂量通心络组(n=10,通心络1·5g/kg·d);(2)小剂量通心络组(n=10,通心络0·5g/kg·d);(3)SHR空白对照组(n=10);(4)同龄雄性正常血压WKY大鼠对照组(n=10)。用无创法测定尾动脉收缩压及心率,至给药12周处死。测定肠系膜动脉分支第3级血管壁(中膜)/腔面积比(W/L)。结果与SHR对照组相比大小剂量通心络组,均能在一定程度上抑制SHR血压升高[184·3±15·1,163·2±9·8vs226·9±14·9)mm Hg,P<0·05]。通心络组治疗后能使SHR大鼠的肠系膜3级血管的血管腔/壁比(L/W)减少。结论通心络可以抑制SHR阻力血管肥厚。Objective To evaluate the effects of Tongxinluo on the structure of resistance vessels in Spontaneously Hypertensive Rats（SHR）. Methods Thirty twelve-week-old male SHRs were divided into three groups at random： untreated control（n=10）, low-dose（0.5 g/kg· d, n=10）, high-dose[1.5 g/kg · d, n=10） Tongxinlou treatment. Tongxinluo, a Chinese herbal compound, were given by garage for 12 weeks, while SHR control group and 10 age and sex-matched Wistar Kyoto rats （WKY） were given tap water. Systolic blood pressure （SBP） and heart rate （HR） were measured using tail-cuff technique. Wall to lumen area ratio （W/L） of mesenteric artery （3rd grade branch） were assessed by morphormetic assay. Vascular reactivity to vasoactive substance were recorded using mesenteric artery rings. Results After 12 weeks treatment, SBP in untreated group is significantly lower both in high and low-dose group than in control group （P〈0.05）. The W/L of mesenteric artery was markedly reduced in the high dose groups than in the control （P〈0.05）. Conclusion Tongxinluo may attenuate vascular hypertrophy in SHR, enhanced vascular sensitivity to vasodilators and attenuate the sensitivity to vasoconstrictors.

关 键 词：通心络 SHR 肠系膜动脉 高血压 阻力血管 

分 类 号：R544.1[医药卫生—心血管疾病]