肾病-肾炎型鸡传染性支气管炎的病理学研究  

Pathological study on chicken nephritis-nephrosis infectious bronchitis

作　　者：齐新永[1] 朱坤熹[2] 

机构地区：[1]上海市畜牧兽医站,上海201103 [2]扬州大学农学院,江苏扬州225009

出　　处：《中国兽医科学》2006年第1期52-56,共5页Chinese Veterinary Science

摘　　要：对43只14日龄的SPF鸡人工感染从上海市分离获得的1株肾致病型鸡传染性支气管炎病毒（上海株IBV），分别于接种后第2、7、14、24、28和36d扑杀，对肾、肺等组织器官进行了动态病理学观察。结果显示，感染鸡主要表现呼吸系统和泌尿系统的病理变化。在感染后的第2d，支气管和气囊呈急性炎症变化；第5d肾实质变性坏死，炎性细胞浸润，肺充血；第8～13d，肾和肺的病变最为严重；第14d后，支气管和输尿管转变为慢性炎症，肾出现弥漫性或局灶性间质性肾炎病理变化。将M41标准毒株与上海株IBV的致病力进行比较，发现2个毒株引起的呼吸器官病变基本相同，但M41，毒株对肾的致病力较轻，未见间质性肾炎和输尿管炎病理变化。证实，上海株IBV主要侵害肺和肾，并造成肾实质变性坏死和间质性肾炎变化。Forty-three 2-weeks-old SPF chickens were inoculated with a nephropathogenic strain of IBV isolated from Shanghai Municipality （Shanghai strain）, and were necropsied on day 2,7,14,24,28 and 36 post-infection, respectively. Studies on dynamic pathology of organs such as kidneys and lungs indicated that gross lesions were mainly present in respiratory system and urinary system. Histopathological examination of organs such as kidneys and lungs showed that bronchus and air sac appeared acute inflammation on day 2 and degeneration and necrosis of renal parenchyma on day 5 post-infection, and inflammatory cells soaked and lungs congested. Lesions of kidneys and lungs were most severe between 8-13 d post-infection. On day 14, Bronchus and ureter transformed chronic inflammation, and the kidneys showed disperse or local interstitial nephritis. Pathogenicity comparison among the Shanghai strain, M41, and the standard strain showed that M41 strain resulted in degeneration of renal parenchyma and could not cause interstitial nephritis and ureteritis. Results demonstrated that IBV Shanghai strain can impair lungs and kidneys, and lead to degeneration and necrosis of renal parenchyma and interstitial nephritis.

关 键 词：传染性支气管炎病毒 肾病-肾炎 组织病理学变化 

分 类 号：S852.659.6[农业科学—基础兽医学]