慢性非细菌性前列腺炎患者血清和前列腺液4种细胞因子检测及意义  

Clinical Evaluation of Four Cytokines in Serum and Prostatic Fluid in Chronic Abacterial Prostatitis

作　　者：李树平[1] 孟双艳[2] 李锐[3] 

机构地区：[1]怀化医学高等专科学校检验系,湖南怀化418000 [2]怀化市第一人民医院检验科,湖南怀化418000 [3]怀化医学高等专科学校附属医院检验科,湖南怀化418000

出　　处：《中华男科学杂志》2006年第1期25-27,共3页National Journal of Andrology

基　　金：湖南省教育厅科研基金资助(03C041)

摘　　要：目的:探讨血清和前列腺按摩液(EPS)中细胞因子与慢性非细菌性前列腺炎(CAP)的关系。方法:用ELISA法对86例CAP患者(其中CAPⅠ组60例,WBC≥10个/HP;CAPⅡ组26例,WBC<10个/HP)血清和EPS进行白细胞介素2(IL-2)、IL-4、IL-8、肿瘤坏死因子α(TNF-α)检测,同时,以20例健康男性作对照,并对所获得的数据进行统计学分析。结果:CAPⅠ组血清和EPS中的IL-2、IL-8、TNF-α,以及血清IL-4均有不同程度的升高,与对照组相比差异有显著性(P<0.05或P<0.01),EPS中的IL-4在CAPⅠ组、CAPⅡ组、对照组间比较差异无显著性(P>0.05),CAPⅡ组血清和EPS中的IL-2、IL-4、TNF-α与对照组相比无显著性差异(P>0.05);EPS中WBC数与IL-8水平存在相关性(r=0.62,P<0.05)。结论:IL-2、IL-8、TNF-α水平可能在CAP发生发展过程中起作用,对CAP的辅助性诊断和分型有一定应用价值。Objective： To investigate the relationship between four cytokines in serum and prostatic fluid and chronic abacterial prostatiffs（CAP）. Methods： The levels ofinterleukin-2（IL-2）, IL-4, IL-8, tumor necrosis factor-α（TNF-α） were detected in 86 patients with CAP[ CAP Ⅰ （n =60）, WBC≥10/HP; CAP Ⅱ （n=26, WBC 〈 10/HP）], and 20 healthy males as control by ELISA. Results： IL-2, IL-8 and TNF-α in serum and prostatic fluid, and IL-4 in serum in patients with CAP I were markedly higher than those in the control, respectively（P 〈0.05 or P 〈0.01 ）. No significant difference was observed in IL-4 level in prostatic fluid among CAP Ⅰ , CAP Ⅱ and control groups respectively（ P 〉0.05 ）, and in IL-2, IL-4, TNF-α in serum and prostatic fluid between CAP Ⅱ group and the control（ P 〉 0.05 ）. IL-8 was correlated with WBC number in prostatic fluid （ r = 0.62, P 〈 0.05 ）. Conclusion ： IL-2, IL-8, TNF-α may play roles in the process of pathogenesis of CAP, and they have applicable value in the diagnosis and typing of CAP.

关 键 词：慢性非细菌性前列腺炎 细胞因子 白细胞介素 肿瘤坏死因子 

分 类 号：R697.3[医药卫生—泌尿科学]