附睾特异性基因的表达与调控  

Specialized Gene Expression and Regulation in the Epididymis

作　　者：曹少锋[1] 徐晨[1] 

机构地区：[1]上海交通大学医学院组织胚胎学教研室

出　　处：《中华男科学杂志》2006年第1期71-74,共4页National Journal of Andrology

摘　　要：哺乳动物的附睾是一条高度卷曲的管道系统,附睾上皮是执行附睾功能的重要组成部分。附睾上皮蛋白质的合成与分泌,为精子提供了一个特殊的、不断改变的管腔液体环境,使其在附睾内运行过程中获得运动能力并最终达到功能成熟。附睾特异性表达的基因具有高度区域化的特征,受雄激素和(或)睾丸因子的调控,在出生后发育中呈现时空特异性的表达模式,这些都提示它们在附睾中发挥着重要而独特的作用。The epididymis is a single and highly convoluted tubule system in mammals. The epithelium is the major compartment for epididymal function. Proteins synthesized and secreted by epididymal epithelium provide a special and ever-changing luminal fluid environment for sperm as they progress through the epididymis, which makes sperm achieve motility and ultimately results in sperm functional maturation. Specialized genes expressed in the epididymis have regional-specific characteristics. They are regulated by androgen and/or testicular factors and present spatial and tempal-specialized expression pattern in postnatal development, all these hint that they play important and unique roles in epididymis.

关 键 词：附睾 基因表达 调控 

分 类 号：Q953[生物学—动物学]