超临界抗溶剂技术制备聚乳酸微粒及表征  

PREPARATION AND CHARACTERIZATION OF PLLA MICROPARTICLES BY SUPERCRITICAL CO_2 ANTISOLVENT TECHNOLOGY

作　　者：滕新荣[1] 任杰[1] 张鹏[1] 

机构地区：[1]同济大学材料学院纳米与生物高分子材料研究所,上海200092

出　　处：《高分子材料科学与工程》2006年第1期195-198,共4页Polymer Materials Science & Engineering

基　　金：上海纳米科学技术专项基金资助(0452nm059:0500236082)

摘　　要：超临界二氧化碳抗溶剂(SA S)技术可用来制备用于药物控释体系的载药聚合物超细粒子。本实验采用SA S过程制备并表征了作为药物缓释制剂的可生物降解聚乳酸微粒,得到了球形或椭圆形的PLLA粒子,并研究了聚合物分子量等对微粒形成的影响。此外还对PLLA载药微粒的载药量进行了测定。这项工作为载药微粒的进一步制备和研究奠定了基础。Supercritical carbon dioxide anti-solvent （SAS） technique has been applied to prepare super-microparticles, which can be used in drug delivery systems. In this paper, PLLA blank and pharmaceutical particles have been prepared successfully by SAS processing and spherical or elliptical particles were obtained. The effects of molecular weight of PLLA on the morphology of particles were studied in detail. Besides, the drug entrapment efficiency of compound particles were measured and analysed. This work provides a groundwork for further studying degradable pharmaceutical particles using SAS technology.

关 键 词：超临界抗溶剂 聚乳酸 药物 

分 类 号：TB44[一般工业技术]