司丙红毒素对大鼠致畸性研究  

Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats

作　　者：潘经媛[1] 邱银生[1] 严汉池[1] 凌飒[1] 

机构地区：[1]湖北省医药工业研究院药理毒理实验中心,湖北武汉430061

出　　处：《癌变．畸变．突变》2006年第1期32-34,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：湖北省重点科技项目(2000LP1602)

摘　　要：背景与目的：观察司丙红霉素对大鼠的致畸毒性。材料与方法：应用SD大鼠进行致畸毒性研究，以75，200和400mg／kg3个剂量组给药，并设阴性对照组（0．5％羧甲基纤维素纳）及阳性对照组（水杨酸钠）给药时间为大鼠妊娠后第6-15d。结果：200和400mg／kg组妊娠大鼠在给药后出现厌食、活动减少，对妊娠大鼠各期体重增长值进行t检验，显示200、400mg／kg组大鼠妊娠10-13d时体重增长值明显低于阴性对照组，停药后体重增长正常；各剂量组妊娠大鼠生育能力与阴性对照组比较无差异；各剂量组与阴性对照组胎仔的外观未见畸形，胎仔的身长、尾长经t检验，差异无统计学意义。胎仔骨骼、内脏发育未见异常。结论：中、高剂量组对妊娠大鼠有母体毒性，表现为体重下降、厌食，但无胚胎毒和致畸作用。BACKGROUND ＆ AIM： To investigate the teratogenicity of erythromycin propionate-N-acetylcysteinate （EPAC） in rats. MATERIAL AND METHODS： SD rats were used in this teratogenicity study. On days 6-15 of pregnancy, SD rats received the drug in three doses of 75, 200, and 400 mg/kg. RESULTS： After oral administration of EPAC, pregnant rats in the groups of 200 and 400 mg/kg doses had signs of anorexia, and decreased activity. The results showed that the body weight gains of pregnant rats on days 10- 13 were significantly lower in the groups of the doses of 200 and 400 mg/kg than in the control group, and recovered to normal after the withdrawal of the drug. The fertility of pregnant rats was not different in each group compared with the control group. No morphologic malformation of rat fetuses was observed in each group compared with those in the control group. The body length and tail length of rats were not significantly different in each group. No abnormality was observed in the growth of bones and internal organs in rat fetuses in all groups. CONCLUSION： EPAC in the doses of 200 and 400 mg/kg has maternal toxicity in pregnant rats, characterized by decreased body weight and anorexia, but has no fetal toxicity or teratogenicity.

关 键 词：司丙红霉素 大鼠 胚胎毒性 致畸作用 

分 类 号：R978.15[医药卫生—药品] R595.3[医药卫生—药学]