自发高血压大鼠心肌肥厚与心室颤动阈值的关系  

Relation Between Hypertrophied Myocardium and Ventricular Fibrillation Threshold in Spontaneously Hypertensive Rats

作　　者：黄至斌[1] 伍卫[1] 韦育林[1] 方昶[1] 邓义军[1] 

机构地区：[1]中山大学附属第二医院心内科,广东广州510120

出　　处：《中山大学学报（医学科学版）》2006年第1期76-79,共4页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：目的探讨自发高血压大鼠心肌肥厚与心室颤动阈值的关系。方法20只雄性自发高血压大鼠,随机分成10周龄组(n=10)和18周龄组(n=10);10只10周龄雄性Wistar大鼠为对照组。分别测定3组大鼠的动脉收缩压、心脏质量指数、心室有效不应期和心室颤动阈值。结果①自发高血压大鼠的动脉收缩压和心脏质量指数明显高于Wistar大鼠(P<0.001),心室颤动阈值明显低于Wistar大鼠(P<0.001);②自发高血压大鼠中,18周龄自发高血压大鼠的动脉收缩压和心脏质量指数明显大于10周龄自发高血压大鼠(P<0.001),心室颤动阈值明显低于10周龄自发高血压大鼠(P<0.001);③不同周龄自发高血压大鼠和Wistar大鼠之间,心室有效不应期没有明显差异(P>0.05);④Wistar大鼠中心脏质量指数与动脉收缩压及心室颤动阈值均无明显相关关系,不同周龄自发高血压大鼠中,心脏质量指数与动脉收缩压及心室颤动阈值均呈明显相关关系;动脉收缩压和心脏质量指数与心室颤动阈值呈负相关(P<0.001);⑤心脏质量指数、动物周龄和种类是影响心室颤动阈值的主要因素(P<0.001)。结论肥厚心肌的心室颤动阈值降低;动脉收缩压愈高,心肌肥厚程度愈明显,心室颤动阈值愈低。[Objective] To investigate the relation between hypertrophied myocardium and the ventricular fibrillation threshold in spontaneously hypertensive rats （SHR）. [Methods] Twenty male SHR were randomly divided into two groups： 10-weck group （n=10） and 18-weck group （n=10）. 10-weck male Wistar rats were controlled group （n=10）. The systolic blood pressure （SBP）, heart mass index （HMI）, ventricular effective refractory period （VERP） and ventricular fibrillation threshold （VFT） were measured respectively. [ Results ] ①The SBP and HMI of SHR were significantly higher than those of Wistar rats（P〈 0.001 ）. The VFT of SHR were significantly lower than that of Wistar rats（P〈 0.001）. ②In SHR, the SBP and HMI of 18 weeks SHR were significantly higher than those of 10-week SHR （P〈 0.001）. The VFT of 18-week SHR were significantly lower than that of 10-week SHR（P〈 0.001）. ③There were no significant difference of VERP among 10 weeks SHIL 18 weeks SHR and Wistar rats（P 〉0.05）. ④There was no relationship between HMI and VFT or SBP in Wistar rats. There was significant relationship between HMI and VFT or SBP in different age spontaneously hypertensive rats. ⑤HMI, age and species of avimal were the major influent factors of VFT.[Conclusion] The VFT of hypertrophied myocardium decreases. The higher the degree of hypertrophy of myocardium and the higher the systolic blood pressure are, the lower the ventricular fibrillation threshold is.

关 键 词：肥厚心肌 电生理 心室颤动阈值 

分 类 号：R544.1[医药卫生—心血管疾病]