聚丙交酯-乙交酯聚合物(PLGA)涂层体外降解行为研究  

Investigation of degradation of PLGA polymer film in simulated body's liquid

作　　者：张萌[1] 齐民[1] 刘洪泽[1] 杨璠[2] 赵红[1] 杨大智[1] 刘炼[2] 

机构地区：[1]大连理工大学材料系三束材料改性国家重点实验室,辽宁大连116024 [2]大连理工大学化工学院高分子系,辽宁大连116012

出　　处：《功能材料》2006年第2期277-280,共4页Journal of Functional Materials

基　　金：国家高技术研究发展计划(863计划)资助项目(2002AA326010)

摘　　要：为了防止心血管支架植入后再狭窄的发生,目前采用将抑制平滑肌细胞生长的药物通过高分子载体涂在支架表面。由于支架植入体内后,涂层受到血液冲刷作用。本工作采用可降解高分子材料PLGA作为载体,将PLGA薄膜置于体外循环冲刷装置中,在37℃、pH7.4的Hank’s模拟体液、模拟血流冲刷作用下的体外降解,并与静态降解作为对比。采用SEM、GPC1、H-NMR和DSC技术研究了聚合物在降解过程中形貌、分子量及分子量分布、失重率、组成和热性能的变化,并对降解机理进行探讨。与静态降解相比较,在流动体液中,高分子载体表面形貌、失重率以及分子量变化均较慢。上述结果与表面微环境有关。In order to avoid the restenosis after percutaneous transluminal coronary angioplasty （PTCA）, the drug-loaded polymer coating is prepared on the surface of stents to prevent proliferation of smooth muscle cell. In this work,we use degradable polymer named PLGA as the coating of stents,and place the PLGA membrane into the in--vitro circulation device in pH7.4 Hank＇s simulation body＇s liquid at 37℃ to simulate the in-vivo degradation under the blood washing influence. To evaluate the effect of flowing to the degradation of PLGA, both the dynamic and static degradation were performed. The changes of molecular weight,molecular weight distribution （polydispersity）, loss weight, composition of the polymer and thermal properties were determined by SEM,GPC,^1H-NMR and DSC techniques, furthermore the dynamic and static degradation mechanism is discussed. The results show that in flowing solution, the changes of morphology, weight and molecular weight were more slowly compared with static degradation. That attributes to the micro-circumstance on polymer surface.

关 键 词：聚丙交酯-乙交酯 体外循环 降解机理 

分 类 号：O63[理学—高分子化学]