大鼠腹主动脉移植排斥反应的实验研究  

Experimental study on the rejection in artery transplantation of rats

作　　者：仇宇[1] 祝青国[1] 陈照彦[1] 高治忠[1] 王赫[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院泌尿外科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2006年第1期45-47,共3页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D9902)

摘　　要：目的建立大鼠腹主动脉移植慢性排斥反应的模型,观察移植动脉的变化规律。方法应用病理图像分析移植后动脉慢性排斥的变化,并结合免疫组化观察转化生长因子-1β(TGF-β1)在慢性排斥反应中的表达。结果移植术后动脉内膜增生并持续增厚,TGF-β1在移植动脉内膜大量表达并与病理改变相关。结论①大鼠移植动脉变化具有内膜增生,中层细胞坏死、迁移,炎性细胞浸润等特点。②TGF-β1在慢性排斥的发生发展中起着重要作用。Objective To establish the experimental animal model of transplantation rejection and observe the performance of transplanted of abdominal aorta tissues. Methods The rat model of artery aUograft was developed. The grafts were collected to receive hnmunohistochemical and histopathological examinations and quantitative measurement of TGF-β1 expression. Results The thickening appeared after operation, strongly expressed TGF-β1 in intima of artery during the episode of rejection..Conclusion Three characteristics including intima hyperplasia, media necrosis and cell migration and inflammatory cell infiltration are demonstrated in the model. The expression level of TGF-β1 was related to the occurrence and development of rejection.

关 键 词：动脉移植 转化生长因子-Β1 慢性排斥 

分 类 号：R332[医药卫生—人体生理学]