葡甘聚糖-胶原蛋白-壳聚糖共混膜(I)  

Konjac Glucomannan-collagen-chitosan Blend Films(I)

作　　者：王碧[1] 王坤余[2] 但卫华[2] 张廷有[2] 叶勇[2] 

机构地区：[1]内江师范学院化学与生命科学系 [2]四川大学皮革化学与工程教育部重点实验室

出　　处：《生物医学工程学杂志》2006年第1期102-106,共5页Journal of Biomedical Engineering

基　　金：国家863高技术发展计划资助项目(2001AA326090)

摘　　要：用溶液共混法制备了葡甘聚糖-胶原蛋白-壳聚糖(KCCS)共混膜。并用FT-IR,X-RD,SEM及透光率表征了膜的结构,同时测试了膜的抗张强度、断裂伸长率、吸水率、透水汽性、渗透性和吸附性。结果表明:共混膜中葡甘聚糖、胶原蛋白及壳聚糖之间存在着强烈的相互作用和良好的相容性,三者共混明显改善了纯聚合物和二元膜的性能。以共混膜为载体培养内皮细胞,发现共混膜具有良好的细胞相容性,预示着共混膜可作为潜在的组织工程支架材料。Konjac glucomannan-collagen-chitosan blend films were prepared successfully by the solventcasting method and were characterized by FT-IR,X-ray diffraction,SEM and optical transmittance. Moreover, tensile strength, breaking extension, water absorption, water vapor permeation coefficients, adsorbability and penetrating rates were measured. The results indicated that some strong interaction and good compatibility existed among Konjac glucomannan /collagen and chitosan in the blend films. Some properties of the KCCS films were improved markedly in comparison with binary blend films or Konjac glucomannan, collagen and chitosan film. The results of culturing vessel endothelial cells on CKCS-5 film showed that the blend films have good cell compatibility which indicates the potential for a scalfold material in tissue engineering.

关 键 词：葡甘聚糖 胶原蛋白 壳聚糖 共混膜 细胞相容性 

分 类 号：R318.08[医药卫生—生物医学工程] R332.2[医药卫生—基础医学]