基因工程内皮细胞种植人工血管的研究进展  

Progress in Studies of Seeding Genetically Engineered Endothelial Cell on Artificial Vascular Graft

作　　者：王文林[1] 蔡开灿[2] 王武军[2] 

机构地区：[1]广州军区总医院心胸外科,广州510010 [2]南方医科大学南方医院心胸外科,广州510515

出　　处：《中国胸心血管外科临床杂志》2006年第1期39-42,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：自体和非自体的生物血管不能满足临床血管外科的需要。使用理化方法或单纯种植内皮细胞的方法处理人工血管因腔内血栓形成而效果不理想。为了增加人工血管的抗血栓活性,利用基因工程的方法对内皮细胞进行改造,可使其获得稳定表达抗凝血因子的能力。用这种基因工程改造的内皮细胞种植于人工血管,有可能获得较理想的效果。而最终要获得理想的血管移植物,尚有许多需要解决的问题。The autograft and non-autograft cannot meet the needs of clinical vascular surgery. Since there are possibilities of thrombus formation in artificial vascular grafts, the methods for deposing the graft using physical and chemical ways or simply seeding with endothelial cells cannot produce satisfactory grafts for vascular operations until now. In order to increase the anticoagulative capacity of artificial vascular graft, it is rational to use genetic engineering methods modifying the endothelial cells to make it express anticoagulative factors stably. Although seeding artificial graft with the genetically engineered endothelial cells can possibly produce a satisfactory graft for vascular surgery, some problems still need to be solved.

关 键 词：基因工程 内皮细胞 人工血管 

分 类 号：R318.1[医药卫生—生物医学工程]