模拟失重对红核神经元超微结构的影响  

Effects of Simulated Weightlessness on Ultrastructure of Red Nucleus Neuron of Rats.

作　　者：朱永进[1] 吴苏娣[1] 樊小力[1] 宋新爱[1] 

机构地区：[1]西安交通大学医学院生理学教研室环境与疾病相关基因教育部重点实验室,陕西西安710061

出　　处：《航天医学与医学工程》2006年第1期23-25,共3页Space Medicine & Medical Engineering

基　　金：国家自然科学基金(30300106)

摘　　要：目的观察模拟失重对红核神经元超微结构的影响。方法采用大鼠尾部悬吊法建立模拟失重动物模型,按体重配对原则随机将大鼠分为3组,即模拟失重14d组、21d组和正常对照组,每组6只。在透射电镜下对红核取材标本进行观察并拍照。结果模拟失重14d组的红核神经元与正常对照组相比,细胞核略有畸型,核仁染色质溶解、边移,局部核膜连续性中断,核膜内折,核质电子密度增加；线粒体增生、肿胀呈球形；失重21d组其退行性改变更为严重。结论模拟失重可致红核神经元超微结构明显的退行性改变,且随失重时间的延长而加重。Objective To study the changes in ultrastructure of red nucleus neurons induced by simulated weightlessness in rats. Method The model of weightlessness was simulated by tail-suspended female rats, all rats were randomly divided into 3 groups： 14 d,28 d tail-suspended and control groups,with 6 rats in each group. Ultrastructure of red nucleus neurons was observed by transmission electron microscopy（TEM）. Result Dysplastic nucleus, hyperplasia of mitochondrion and some characterized changes were found in red nucleus neurons in 14 d tail-suspended rats, and serious degeneration was found in red nucleus neurons in 21 d tail-suspended rats as compared to control rats. Conclusion Simulated weightlessness can induce obvious time-related changes on ultrastructure of red nucleus neurons in rats.

关 键 词：失重模拟 红核 神经元 超微结构 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]