芪丹通脉片对大鼠血栓形成及血液粘度的影响  

Effects of Qidan Tongmai Tablet on Thrombus Formation and Blood Viscosity in Rats

作　　者：龙铟[1] 王宗仁[1] 马静[1] 行利[1] 李晶华[1] 林成仁[2] 

机构地区：[1]中国人民解放军第四军医大学西京医院中医科,邮政编码西安710032 [2]中国中医研究院西苑医院

出　　处：《微循环学杂志》2006年第1期37-39,共3页Chinese Journal of Microcirculation

基　　金：全军医药卫生科研基金课题(2000B07)

摘　　要：冠心病是临床上最常见的心脏病，也是危害人类健康和生命的主要心血管病之一，目前在我国的发病率、死亡率呈上升趋势，治疗费用是预防费用的数十倍到数百倍，极大地增加了个人和社会的经济负担。因此，研制防治冠心病的药物有着重要的临床意义和价值。实验研究已证实，纯中药制剂芪丹通脉片能改善心肌缺血，防治冠心病。为进一步研究芪丹通脉片的药理机制，本实验观察其对大鼠体外血栓形成、凝血时间和血液粘度的影响。Objective: To study effects of Qidan Tongmai Tablet (QDTMT), a compound preparation made up of pure traditional Chinese medicine, on thrombus formation, plasma coagulation time and blood viscosity in Wistar rats. Method: The suspension of QDTMT was given to Wistar rats by gastrogavage for 7 days and the indexes of thrombus length, wet weight, dry weight, prothrombin time(PT), kaolin partial thromboplastin time(KPTT),thrombin time(TT) and whole blood viscosity(ηb) were detected.Results: Compared with control group, QDTMT_ max and QDTMT_ mid markedly shortened thrombus length(P<0.05～0.01), wet weight and dry weight of thrombus(P<0.01), extended PT, KPTT and TT(P<0.05), reduced whole blood mid-shear(ηbm) and low-shear viscosity (ηbl) (P<0.05).Conclusion: QDTMT can significantly inhibit thrombus formation, extend blood coagulation, reduce blood viscosity and the effects are dosage-dependent.

关 键 词：体外血栓形成 芪丹通脉片 血液粘度 大鼠 临床意义 纯中药制剂 冠心病 心血管病 人类健康 上升趋势 

分 类 号：R285.5[医药卫生—中药学] R446.11[医药卫生—中医学]