酒精联合高脂饮食对大鼠血脂与脂质过氧化的影响  

Study on the Blood Lipids and the Lipid Peroxidation of Rats Induced by Alcohol and High Fat Diet

作　　者：李友[1] 贺彬琪[1] 让蔚清[1] 

机构地区：[1]南华大学公共卫生学院卫生学教研室,湖南衡阳421001

出　　处：《美国中华临床医学杂志》2005年第4期320-322,共3页American Journal of Chinese Clinical Medicine

摘　　要：目的 研究不同浓度的白酒和高脂对大鼠的损伤作用压VitE的保护作用。方法 用灌胃白酒及喂饲高脂饮食的方法，观察脏器系数的改变和血清中MDA、葡萄糖（Glu）、总胆固醇（T-CHO）、甘油三酯（TG）含量变化。结果 肝脏的脏器系数在高荆量酒精、高脂组及高脂联合中剂量酒精组差异有显著性，高脂加中剂量酒精组和中剂量酒精组比较差异有显著性。心脏的脏器系数只在高剂量酒精组有统计学意义，肾脏的脏器系数各组间无显著性差异，MDA含量与肝脏的脏器系数改变趋势一致，VitE使MDA、Glu、T-CHO、TG下降，随着胃饲时间的延长，血清中Glu、T-CHO、TG逐渐递增，差异有显著性。结论 高剂量酒精、高脂及高脂联合中剂量酒精对大鼠肝脏有一定的损伤作用，使血清中葡萄糖、总胆固醇、甘油三酯的含量增高，高脂加重了酒精对肝脏的损伤，而高荆量酒精对心脏也有一定程度的损伤作用，可能与脂质过氧化引起自由基损伤有关，VitE对其损伤作用有一定的保护作用。Objective To investigate the comprehensive damage of rats induced by alcohol and high fat diet and the protection of VitE, Methods Male SD rats were reared with different doses alcohol and high fat diet for 8 weeks.Serum MDA,Glu,T- CHO,TG level and organs relative weight of heart, hepatin and kidney were examined. Results the organs relative weight of hepafin of high fat diet group, alcohol（56V/V）, and high fat diet and alcohol（28V/V） group were significantly increased than normal group. The organs relative weight of heart of alcohol （56V/V） group was significantly increased than normal group. The organs relative weight of kidney did not change significantly. The trend of MDA ,Glu ,T - CHO ,TG was similar to organs relative weight of hepatin . All parameters was significantly decreased in high fat diet and alcohol（28V/V） and VitE group . With the passing of time, GIu,T- CHO,TG was significantly increased than before. Conclusion High fat diet ,alcohol （56V/V）, high fat diet and alcohol（28V/V） could lead to liver injury and alcohol （56V/V） could lead to heart injury. These could be in relation with the lipid peroxidation and VitE can protect from these damages.

关 键 词：酒精 高脂 大鼠 脏器系数 

分 类 号：R589.2[医药卫生—内分泌] R285.5[医药卫生—内科学]