雌/孕激素受体和HOXA-9基因在输卵管和异位妊娠输卵管中的表达  

Expression of Estrogen Receptor, Progesterone Receptor and HOXA-9 Gene in Human Fallopian Tube and Ectopic Pregnant Fallopian Tube

作　　者：王莉芬[1] 蔺昕燕[1] 范成明[1] 张文波[1] 吕丽[1] 王乃玉[1] 

机构地区：[1]大连医科大学附属第二医院,大连116027

出　　处：《生殖与避孕》2005年第9期527-530,526,共5页Reproduction and Contraception

摘　　要：目的:探讨雌激素受体(ER)、孕激素受体(PR)和HOXA-9基因在人输卵管中的表达及与输卵管妊娠的关系。方法:采用免疫组化和原位杂交方法对34例正常输卵管和38例妊娠输卵管黏膜中ER、PR和HOXA-9基因表达进行研究。结果:ER、PR在正常增生期和分泌期输卵管黏膜上皮中的表达率较高;在妊娠输卵管黏膜上皮中的表达率明显下降(P<0.01)。HOXA-9基因在正常增生期输卵管中的表达率较高,分泌期输卵管中表达降低,而在妊娠输卵管中表达率又有所增高(高于分泌期输卵管的表达率,P<0.05)。结论:ER、PR在输卵管黏膜上皮中的表达下降和HOXA-9基因表达增强与输卵管妊娠密切相关;在正常分泌期输卵管黏膜上皮中,ER、PR表达水平上调和HOXA-9基因表达下调可能起着屏障作用,防止输卵管着床的发生。Objective： To investigate the expression of estrogen receptor （ER）, progesterone receptor （PR） and HOXA-9 gene in human fallopian tube and pregnant fallopian. Methods： The expression ofER, PR and HOXA- 9 gene was detected in 34 samples of normal oviduct and 38 samples of pregnant fallopian by immunohistochenmistry and in situ hybridization, respectively. Results： The expression level of ER and PR was higher in normal oviduct. There was a significant decrease in ER and PR concentration in pregnant fallopian tube （P〈0.01）. HOXA-9 gene expression was noted in epithelial ceils of both normal and pregnant fallopian tube, but the intensity of staining in pregnant fallopian tube was much higher （P〈0.05）. Conclusion： It is postulated that decrease in ER and PR expression and increase in HOXA-9 gene expression is correlated with the fallopian pregnancy. It is possible that during secretory phase, up-regulated expression of ER and PR and down-regulated expression of HOXA-9 gene in normal fallopian tube act as a barrier and avoid the tubal pregnancy.

关 键 词：雌激素受体 孕激素受体 HOXA-9基因 输卵管 妊娠 

分 类 号：R714.22[医药卫生—妇产科学]