吲哆美辛-微米铜-聚乙烯复合材料体外释放的研究  

Slow Release of Polyethylene Matrix Composites Containing Copper and Indomethacin in vitro

作　　者：向华[1] 蔡水洲[1] 夏先平[1] 杨志红[1] 谢长生[1] 

机构地区：[1]华中科技大学塑性成型模拟及模具技术国家重点实验室,武汉430074

出　　处：《生殖与避孕》2005年第12期732-737,共6页Reproduction and Contraception

基　　金：国家自然科学基金(编号:50271029)国家"十五"攻关项目(No.2004BA709B14-01)资助

摘　　要：目的:探讨吲哆美辛-微米铜-聚乙烯复合材料中吲哆美辛和Cu2+的体外释放。方法:用 紫外分光光度法对压制成型的复合材料中吲哆美辛和Cu2+的体外释放进行了为期45 d的测 定。结果:吲哆美辛和Cu2+的释放都具有缓释特性,释放曲线呈现指数型;释放过程中,吲 哆美辛和Cu2+之间没有明显的化学干扰。结论:复合材料中吲哆美辛的存在对Cu2+的释放有 促进作用,并且Cu2+的释放速率随吲哆美辛含量的增大而增大。Objective： To prepared indomethacirdcopper/polyethylene composites with various mass fractions of copper microparticles and indomethacin powder by process forming. Method： The daily release amounts of Cu^2＋ and indomethacin in the first 45 days were determined by ultraviolet spectrophotomerry. Results： The composites have identical features on slow release, it was found that no obvious interference between Cu^2＋ and indomethacin existed in simulated uterine solutions during analysis. Cu^2＋ release rate was accelerated because of the existence of indomethacin and morc mass fractions of indomethacin resulted the higher release rate.

关 键 词：吲哆美辛 缓释体系 CU-IUD X-射线衍射法(XRD) 

分 类 号：R318.08[医药卫生—生物医学工程]