作为潜在抗癌试剂的单取代(环氧丙烷氨基)蒽醌的合成(英文)  

Synthesis of mono-(epoxypropylamino)anthraquinone derivatives as potent antitumor agents

作　　者：张昱[1] 卢俊瑞[1] 

机构地区：[1]天津理工大学生物与化学工程学院,天津300191

出　　处：《天津理工大学学报》2006年第1期13-15,共3页Journal of Tianjin University of Technology

基　　金：国家自然科学基金(20376063);天津市自然科学基金(043610511)

摘　　要：1氨-基蒽醌和环氧丙烷发生N-烷基化反应合成出1-(环氧丙烷氨基)蒽醌.中间产物的侧链3氯--2-羟基丙氨基在碱性水溶液的后处理过程中,发生闭环反应生成环氧乙烷环(氨基).考查了中间体1-(3氯--2羟-基丙氨基)蒽醌在碱催化下,与水以及脂肪胺的反应.1-（epoxypropylamino）anthraquinone was synthesized from 1-aminoanthraquinone I and by N-alkylation reaction, being treated with epoxy compounds such as epichlorohydrin, and then the ring-closing of side chain 3-chloro-2-hydroxypropylamino-formed oxirane ring in the side chain in the course of their work-up by alkali aqueous solutions. The immediate 1-（3- chloro-2-hydroxypropylamino） anthraquinone reacting with water under base catalyst, and fatty amine were investigated.

关 键 词：1-(环氧丙烷氨基)总醌 N-烷基化反应 酸催化 闭环反应 1-(3-氯-2-羟基丙氨基)蒽醌 

分 类 号：O629.9[理学—有机化学]