长期尾部悬吊对大鼠左心室乳头肌等长收缩性能的影响  

Effects of Long-term simulated Weightlessness on Isometric Contractility of Left Ventric-ular Papillary Muscles in Rats

作　　者：马进[1] 张立藩[1] 余志斌[1] 

机构地区：[1]第四军医大学航空生理学教研室

出　　处：《航天医学与医学工程》1996年第1期49-53,共5页Space Medicine & Medical Engineering

摘　　要：观察头低位一３０°尾部悬吊１３周对大鼠左室乳头肌等长收缩性能的影响。结果表明，１３周尾部悬吊大鼠左室乳头肌的静息张力与发展张力较同步对照组分别下降１６％和３３％（Ｐ＜０；０５和Ｐ＜０．０１）；最大张力发展速率与最大张力下降速率分别下降３３％和２８％。当细胞外钙离子浓度分别为０．２５、０．５、１．５、２．５、３．５、４．５．５与６．５ｍｍｏｌＬ时，其发展张力较同步对照均有３１％至３８％的降低。这些变化提示：１３周尾部悬吊使大鼠心肌等长收缩性能明显降低。The effects of long-term simulated weightlessness on the,isometric contractile perormance of Papillary muscles isolated from the left ventricle of rats were examined in modified Morey-Holton's tail-suspension rat medel with the technique of iSolated papillary musclc perfusion.The results were as follows:13w tail-suspension cauwesed 33%and 16% decrease in developed tension and resting tension respectively;significant depression in peak rate of tension rise and peak rate of tension decay were also observed;in addition,the concen-tration response curves of extracellular calcium in papillary muscles from 13w tail-suspended rats shifted downward.Thees data indicate that the isometric contractility of papillacy mus-cles from 13 w tail-suspended rats washwered.

关 键 词：失重模拟 等长收缩 乳头肌 心肌收缩 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]