急性腋静脉血栓形成溶栓治疗过程中血浆CGRP检测的临床意义  

Clinical Significance of Determination of Changes of Plasma Calcium Genetic Related Peptide(CGRP) Levels During Thrombolytic Therapy in Patients with Acute Axillary Venous Thrombosis

作　　者：王春喜[1] 王太晗[1] 梁发启[1] 李荣[1] 王晓玲[2] 孙长江[2] 

机构地区：[1]中国人民解放军总医院,100853 [2]北京市长峰医院,100073

出　　处：《放射免疫学杂志》2006年第1期3-4,共2页Journal of Radioimmanology

摘　　要：目的:探讨急性腋静脉血栓形成溶栓治疗过程中血浆降钙素基因相关肽(CGRP)水平及其临床意义。方法:选择30例急性腋静脉血栓形成溶栓治疗的病人,利用放射免疫分析动态观察其血浆CGRP水平;同时检测30例同龄健康查体者和30例慢性病人血浆CGRP水平。结果:急性腋静脉血栓形成患者存在高CGRP血症,而慢性病人则无明显改变;急性患者溶栓治疗后6h血浆CGRP继续升高,3d达高峰,与临床疗效最佳时间相符。结论:血浆CGRP水平可作为溶栓治疗效果的一种检测指标,并可作为疾病进程的实验室指标。Objective To investigate the clinical significance of plasma CGRP levels determination during thrombolytie therapy in patients with acute axillary venous thrombosis. Methods Plasma CGRP levels were determined with RIA in 30 patients with acute axillary venous thrombosis, 30 patients with chronic axillary venous thrombosis and 30 controls. In the acute patients, plasma CGRP levels were dynamically measured before the therapy and 6h, ld, 3d, 7d, 30d after start of the therapy. Results Before treatment, plasma CGRP levels in the acute patients were significantly higher than those in chronic patients and controls （ 86.70 ± 11.02pg/ml vs 57.68 ± 14.95 pg/ml and 55.71 ± 9.59pg/ml, P 〈 0.01 ）. Mter starting the therapy, the plasma CGRP began to rise further at 6h and reached peak value on the 3rd day when improvement was most marked. Conclusion Plasma CGRP level determination is helpful for judgement of the efficacy of thrombolytic therapy.

关 键 词：腋静脉血栓形成 降钙素基因相关肽 

分 类 号：R714.144[医药卫生—妇产科学] R543.6[医药卫生—临床医学]