慢支咳喘宁胶囊对实验性慢性支气管炎大鼠肺组织中TNF和ET含量的影响  

Effects of Manzhi Kechuanning Capsules on the contents of TNF and ET in the lung tissue of experimental rats with chronic bronchitis

作　　者：刘延祯[1] 田栓磊[1] 王晓莉[2] 李永荣[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]甘肃中医学院附属医院,甘肃兰州730020

出　　处：《甘肃中医学院学报》2006年第1期14-16,共3页Journal of Gansu College of Traditional Chinese Medicine

基　　金：甘肃省科技攻关项目(2GS042-A43-014-21)

摘　　要：目的:探讨慢支咳喘宁胶囊治疗慢性支气管炎的作用机制。方法:采用改良烟熏法复制慢性支气管炎大鼠模型,实验动物随机分为模型对照组、慢支咳喘宁胶囊低剂量组、慢支咳喘宁胶囊高剂量组、气管炎丸组及不加处理的空白对照组。造模各组以高、低剂量慢支咳喘宁胶囊、气管炎丸和生理盐水进行干预,测定各组大鼠肺组织中肿瘤坏死因子(TNF)、内皮素(ET)的含量。结果:模型组大鼠肺组织中TNF和ET的含量均较空白组明显升高(P<0.01);与模型对照组比较,治疗各组肺组织中TNF和ET含量明显降低(P<0.05或P<0.01)。结论:慢支咳喘宁胶囊可降低TNF、ET含量,控制慢性炎症反应。Objective： To investigate the internal mechanism on treating chronic bronchitis of Manzhi Kechuanning Capsules. Methods： Duplicated the animal model of chronic bronchitis with refined smoking-fumigated method, the rats were randomly divided into model group, low dose group, high dose group, Qiguanyan Pills group and normal control group that didn＇ t treated. Made intervention with high and low dose Manzhi Kechuanning Capsules as well as Qiguanyan Pills（ another medicine of the similar kind） and 0.9 % NS, determined the contents of TNF and ET in the lung tissue. Results ： The contents of TNF and ET in the lung tissue of the model group were significantly improved than that of the normal group （ P 〈 0. 01 ）. Compared with the model group,the contents of TNF and ET in the lung tissue of each treating group were significantly reduced （P 〈 0. 05 or P 〈 0. 01 ） . Conclusion： Manzhi Kechuanning Capsules can control chronic inflammatory reac- tion by reducing the contents of TNF and ET.

关 键 词：慢支咳喘宁胶囊 慢性支气管炎 TNF ET 

分 类 号：R285.5[医药卫生—中药学]