休克血浆对离体豚鼠心室乳头肌的电生理效应  

Electrophysiological Effects of Shock Plasma on Guinea Pig Papillary Muscles

作　　者：张晓云[1] 刘艳凯[1] 赵兰平[1] 

机构地区：[1]河北北方学院生理教研室,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2005年第6期17-18,共2页Journal of Hebei North University:Medical Edition

基　　金：河北省卫生厅中医药中西医结合科学研究计划课题(编号:200002)

摘　　要：目的:进一步阐明休克血浆对心肌细胞的影响。方法:本实验利用常规的玻璃微电极细胞内记录技术,观察了休克血浆对豚鼠心室乳头肌动作电位的作用。结果:用含一定浓度的正常血浆灌流时,豚鼠心室乳头肌细胞动作电位的各指标均无显著变化,而用等量的休克血浆灌流,动作电位的APA、OS均显著升高(P<0.05),APD50、APD90、APD也明显延长(P<0.05)。结论:休克血浆可显著影响豚鼠心室乳头肌动作电位APA、OS的高度及动作电位的时程,可能与心肌缺血再灌注心律失常的发生有关。Objective： The purpose of this study was to clarify the actions of shock plasma （Sp）on guinea pig papillary muscles and its mechanism. Methods： By using conventional intracellular microelectrode technique the action potentials were recorded and the electrophysiological effects of SP on guinea pig papillary muscles were observed as well. Results： For normal papillary muscles, normal concentrated plasma didn＇t af- fect on their action potential, but shock plasma not only increased the amplitude of action potential （APA）, overshoot（OS）, but also prolonged the duration of action potential （APD）（P〈0. 05）. Conclusion： The electrophysiological effects of shock plasma on guinea pig papillary muscles are likely resulted from arrhythmia caused by ischemia-reperfusion injury.

关 键 词：心室乳头状肌 动作电位 休克血浆 

分 类 号：R331.3[医药卫生—人体生理学]