抗抑郁药物治疗对心力衰竭合并抑郁病人预后的影响  

The Influence of Antidepressant Drug Treatment on Prognosis of CHF Patients with Depression

作　　者：郜宪林[1] 刘向群[2] 刘金忠[1] 

机构地区：[1]菏泽医学专科学校,山东菏泽274030 [2]山东大学齐鲁医院

出　　处：《菏泽医学专科学校学报》2005年第4期18-20,共3页Journal of Heze Medical College

摘　　要：目的探讨抗抑郁药物治疗(盐酸氟西汀,商品名百忧解)对慢性心力衰竭合并抑郁症患者安全性及其对患者预后,包括住院时间、再入院率、死亡率的影响。方法以Zung抑郁自评量表(SDS)评定212例慢性心力衰竭住院患者,将确定为抑郁症的76例患者分为百忧解治疗组(在常规抗心衰治疗的基础上加服百忧解3个月)及安慰剂组。结果慢性心力衰竭患者抑郁症的发生率为36．8％;抑郁症者住院时间长于无抑郁症组,3个月和6个月死亡率和再入院率高于无抑郁症者(P<0．01);出院时百忧解组抑郁评分明显低于安慰剂组(P<0．01),比治疗前的显著降低(P<0．01);百优解组6个月死亡率和再入院率均低于安慰剂组(P <0．05);百忧解组患者在服药期间未有因胃肠道、心血管等系统的不良反应而停药者。结论抑郁症在慢性心力衰竭患者中的患病率较高;抑郁症是合并抑郁症的心衰患者预后不良的重要危险因子;百忧解可改善心力衰竭合并抑郁症患者的预后,安全性高,抗抑郁效果好,因而可用于此类病人的治疗。Objective To investigate prospectively the reliability, effectiveness and influence of antidepressant drug treatment （Prozac） on prognosis of CHF patients with deprexsion. Methods the total 212 patients with CHF were surveyed using Zung Self - Rating Depression Scale in the next day of hospitalization. A part of the patients with depression were prescnibed Prozac 20mg once everyday （ 3 months）. Follow up for six months to take the length of stay, mortality and readmission rate. Results The incidence of depression in CHF is 36.8%. The patients with depression have the longer length of stay , higher six - month death rate and readmiasion rate （P〈 0.01 ） ; however, all these were decreased strikingly（ P〈 0.05）by antidepressant drug treatment. No obvious ill effect of gastrointestinal tract and cardiovascular system is found during the follow up period. Conclusion The incidence of depression in CHF is high , which is one of significant risk factors of poor prognosis of CHF, Prozac, as a kind of antidepressant drug has good effect and high reliability ; further it can ameliorate prognosis of CHF patients with depression, so can be used in the treatment for such patients.

关 键 词：P心力衰竭/并发症 抑郁症/病因学 药物治疗 

分 类 号：R541.6[医药卫生—心血管疾病]