注意缺陷多动障碍与儿茶酚-○-甲基转移酶基因的关联分析  

Association Analysis Between Catechol-o-methyltransferase(COMT) Gene and ADHD

作　　者：高雪屏[1] 苏林雁[1] 杜亚松[2] 李雪荣[1] 张向晖[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [2]上海市精神卫生中心,上海200030

出　　处：《中国临床心理学杂志》2006年第1期94-97,共4页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金资助(项目号:39770277)

摘　　要：目的:分析COMT基因多态性与ADHD的关联;寻找ADHD的易感基因。方法:采用PCR-RFLP技术,检测54名ADHD患者及其父母(n=82)和正常对照者(n=30)COMT基因Val158Met多态性的基因型和等位基因频率,运用病例对照研究和核心家系的关联分析(HRR和TDT)方法分别进行分析。结果:Val158Met多态性的各基因型和等位基因频率在ADHD组与对照组以及核心家系中的分布差异均无显著性(均P>0.05)。注意缺陷为主型患儿COMT基因的G/G型频率和G等位基因频率明显高于混合型的(P<0.05),A等位基因与ADHD的某些临床症状如注意问题、违纪行为、攻击行为等相关。结论:①COMT基因可能与ADHD缺乏关联,仅起微效基因的作用;②COMT可能与ADHD临床亚型或临床症状有关。Objective： To analyse the association between polymorphisms in human cateehol-o-methyltransferase gene and ADHD, and to find the disease-perdisposing genes of ADHD. Methods： Genotypes and allele frequencies of Val158Met polymorphism at COMT gene in ADHD probands （n=54）, their parents （n=82）, and normal controls （n=30） were examined by PCR, RFLP techniques. Both case-control association study and family-based association study （HRR and TDT analysis） were used. Results： No differences in genotypes and allele frequencies of Val158Met polymorphism at COMT gene were observed between ADHD group and control group （P 〉0.05）, and in nuclear families （P 〉0.05）. The frequencies of genotype G/G and G allele of Val158Met polymorphisn, at COMT gene in ADHD predominantly inattention subtype were significantly higher than those in combined subtype （P〈0.05）. ＂A＂ allele was associated with certain clinical manifestations （attention problems, delinquent behavior and aggressive behavior）. Conclusion： COMT gene was probably not associated with ADHD in this study. COMT gene was probably associated with clinical subtypes and clinical manifestations of ADHD.

关 键 词：注意缺陷多动障碍 COMT基因 关联分析 

分 类 号：R395.2[哲学宗教—心理学]