海尔福口服液对铅中毒小鼠某些生化指标的影响  

Effect of Haierful oral liquid on some biochemical indexes in lead poisoned mice

作　　者：周国荃[1] 张树球[1] 黄秋艳[1] 朱祖华[1] 罗晶丹[1] 吴诗章[1] 莫生琼[1] 农嵩[1] 

机构地区：[1]右江民族医学院重金属与氟砷毒物研究实验室,广西百色533000

出　　处：《中国工业医学杂志》2006年第1期29-31,共3页Chinese Journal of Industrial Medicine

摘　　要：目的研究中草药制剂海尔福口服液对铅中毒小鼠某些生化指标的影响。方法用醋酸铅水溶液给小鼠作腹腔注射连续染毒40 d,染毒两星期后,将小鼠分为(1)口服液治疗组、(2)大蒜治疗组、(3)中毒组、(4)正常对照组。(1)组用海尔福口服液灌胃,(2)组用大蒜提取液灌胃,(3)、(4)组用等体积的生理盐水灌胃,灌胃治疗共26d。测定实验前、后小鼠的血红蛋白(Hb),实验后血清铅、尿素、丙氨酸氨基转移酶(ALT)、高密度脂蛋白中胆固醇(HDL-C)、载脂蛋白-A1(apo-A1)及肝谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)含量。结果中毒组体重和Hb含量明显下降、血清铅升高(P<0.01);治疗(1)、(2)组Hb的含量下降和血铅升高均较轻;中毒组的ALT、尿素、GSH、GSH-Px、死亡率均高于其他各组,而apo-A1低于各组(P<0.05或P<0.01)。结论海尔福口服液对铅中毒小鼠生化指标有较明显的改善作用。Objective To study the curative effect of Haierful oral liquid on lead poisoned mice. Method lead acetate solution was applied to inject the mice ip for40 days, and the mice were divided into 3 groups when experiment was done for two weeks： the Haierful oral liquid treated group （group 1）, the garlic extract treated group （group 2）, and the poisoned group （group 3） .In order to contrast, a control group was added （group 4） .Haierful oral liquid was applied to feed group 1, garlic extract was applied to feed group 2, and physiological salt water was used to feed group 3 and group 4, treating lasts for 26 days. The concentration of Hb before and after the experiment and the concentration of lead , urea, ALT, HDL-C, ape-At, GSH and GSH-Px in sermn after the experiment were determined. Result The concentration of Hb of the poisoned group was declined, while the concentration of lead in serum of that was risen significantly. The concentration of Hb in the Haiefful oral liquid treated group and the garlic extract treated group was declined, but the concentration of lead in serum of those was risen. The concentration of ALT, urea, ALT, GSH and GSH-Px, mortality of the poisoned group were all higher than other groups. But the concentration of ape-A1 was lower than that of other groups （P〈0.05 or P〈0.01）. Condusion The curative effect of Haierful oral liquid on lead poisoned mice is obvious.

关 键 词：铅中毒 小鼠 海尔福口服液 

分 类 号：R315.11[医药卫生—基础医学]