南海海绵Craniella australiensis化学成分研究(Ⅰ)  

Studies on chemical constituents of the marine sponge Craniella australiensis from the South China Sea

作　　者：况夏 张红军[2] 孙晶波[2] 王增蕾[2] 林厚文[2] 

机构地区：[1]广东省深圳市东湖医院,广东深圳518020 [2]第二军医大学长征医院药学部海洋药物实验室,上海200433

出　　处：《中国海洋药物》2006年第1期21-24,共4页Chinese Journal of Marine Drugs

基　　金：国家高技术研究发展计划"863"资助课题(No.2002AA628160;2004AA628050);上海市青年科技启明星计划资助课题(No.02QB14003)

摘　　要：目的对中国南海澳大利亚厚皮海绵Craniella australiensis的化学成分进行研究。方法采用柱色谱分离纯化,通过理化和波谱分析方法鉴定化合物的结构。结果从澳大利亚厚皮海绵乙醇提取物中分离得到了4个单体化合物,分别鉴定为:β-谷甾醇(Ⅰ);3β,6β-豆甾-4-烯-3,6-二醇(Ⅱ);1,12-二氮杂环二十二烷-2,11-二酮(Ⅲ)和尿嘧啶(Ⅳ)。结论所有化合物均为首次从该种海绵中获得。Objective To sis collected from the study the chemical South China Sea. constituents of marine sponge Craniella australien- Methods The compounds were isolated and purified by column chromatography and their structures were identified based on spectral analyses and chemical evidence. Results Four compounds were isolated from the ethanol extract and identified as. β-sitosterol （ Ⅰ ） ; 3β, 6β-stigmast-4-en-3,6-diol （ Ⅱ ） ; 1,12-diazacyclodocosane2,11-dione （Ⅲ ） ; uracil （Ⅳ）. Conclusion All these compounds were isolated from this sponge for the first time.

关 键 词：海绵 化学成分 分离 结构鉴定 

分 类 号：Q959.120[生物学—动物学]