稳定型冠心病行经皮冠状动脉介入治疗后心肌肌钙蛋白I的预测作用  

Prognostic role of cardiac troponin I after percutaneous coronary intervention in stable coronary disease

作　　者：Nageh T. Sherwood R. A. Harris B. M. Thomas M. R. 代喆 

机构地区：[1]Dr. Department of Cardiology,King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第1期53-53,共1页

摘　　要：Objective: To assess the role of cardiac troponin I(cTnI) in predicting outcome after percutaneous coronary intervention(PCI). Methods and results: cTnI was measured immediately before and at 6, 14, and 24 hours after PCI in 316 consecutive patients with stable symptoms and native coronary artery disease. The study end point was the occurrence of major adverse cardiac events(MACE) at 30 days and at 18 months after PCI: death, Q wave myocardial infarction(MI), or repeat revascularisation in hospital. Postprocedural cTnI increased in 31%of patients. The cumulative MACE rate at 18 months was 25%(17.7%due to repeat PCI procedures). There was a significant association between postprocedural cTnI increase and death, Q wave MI, or both(odds ratio(OR) 3.28, 95%confidence interval(CI) 1.7 to 6.4, p=0.01). Post-PCI cTnI increase had a positive predictive value(PPV) for adverse events at 18 months of 0.47 and a negative predictive value(NPV) of 0.96(OR 18.9, 95%CI 9.7 to 37, p< 0.0001). The presence of both a postprocedural cTnI rise and a procedural angiographic complication gave a PPV for adverse events of 0.69 and an NPV of 0.92(OR 22.6, 95%CI 2.6 to 68.6, p=0.0005). Conclusions: cTnI increased post-procedurally in one third of this stable patient population undergoing elective PCI and was independently and significantly predictive of an increased risk of adverse events at 18 months, predominantly in the form of repeat PCI.Objective： To assess the role of cardiac troponin Ⅰ（cTnⅠ） in predicting outcome after percutaneous coronary intervention （PCI）. Methods and results： cTnⅠ was measured immediately before and at 6, 14, and 24 hours after PCI in 316consecutive patients with stable symptoms and native coronary artery disease. The study end point was the occurrence of major adverse cardiac events（MACE） at 30 days and at 18 months after PCI： death, Q wave myocardial infarction （MI）, or repeat revascularisation in hospital. Postprocedural cTnⅠ increased in 31% of patients.

关 键 词：心肌肌钙蛋白Ⅰ(cTnⅠ) 经皮冠状动脉介入 介入治疗后 预测作用 稳定型冠心病 冠心病患者 心脏不良事件 Q波心肌梗死 MACE 累积发生率 

分 类 号：R541.4[医药卫生—心血管疾病] R542.22[医药卫生—内科学]