SUPPRESSION OF CELL ADHESION ON POLYACRYLONITRILE-BASED MEMBRANES BY THE ANCHORING OF PHOSPHOLIPID MOIETIES  

作　　者：Xiao-jun Huang Xiao-dan Huang Ai-fu Che Zhi-kang Xu Ke Yao 

机构地区：[1]Institute of Polymer Science, Zhejiang University, Hangzhou 310027,China [2]Medical College, Zhejiang University, Hangzhou 310027, China

出　　处：《Chinese Journal of Polymer Science》2006年第1期103-106,共4页高分子科学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.50273032).

摘　　要：In this work, the membrane surface of poly（acrylonitrile-co-2-hydroxyethyl methacrylate） （PANCHEMA） was chemically modified by anchoring of phospholipid moieties. The process involved the reaction of hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane （COP） followed by the ring-opening reaction of COP with trimethylamine. Chemical differences between the original and the modified membranes were characterized by FT-IR and XPS, It was found that the amount of macrophage adhered on the modified membrane surface is substantially lower than that on polyacrylonitrile （PAN） and PANCHEMA membranes under the same condition, The morphological change of the adherent cell is also suppressed by the generation ofphospholipid moieties on the membrane surface.In this work, the membrane surface of poly（acrylonitrile-co-2-hydroxyethyl methacrylate） （PANCHEMA） was chemically modified by anchoring of phospholipid moieties. The process involved the reaction of hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane （COP） followed by the ring-opening reaction of COP with trimethylamine. Chemical differences between the original and the modified membranes were characterized by FT-IR and XPS, It was found that the amount of macrophage adhered on the modified membrane surface is substantially lower than that on polyacrylonitrile （PAN） and PANCHEMA membranes under the same condition, The morphological change of the adherent cell is also suppressed by the generation ofphospholipid moieties on the membrane surface.

关 键 词：Acrylonitrile copolymer Membrane Surface modification Phospholipid moieties Cell adhesion. 

分 类 号：TQ316.6[化学工程—高聚物工业]