模拟失重时兔微循环的动态变化  

Dynamic Changes of Microcirculation in Rabbits under Simulated Weightlessness

作　　者：向求鲁[1] 沈羡云[1] 刘光远[1] 

机构地区：[1]航天医学工程研究所

出　　处：《航天医学与医学工程》1996年第1期1-6,共6页Space Medicine & Medical Engineering

摘　　要：用家兔以头低位－２０°方法模拟失重时体液头向分布和运动减退生理效应的模型。用兔耳不开窗微循环观察方法，动态地研究机体在模拟失重时表浅微血管中血液流动状态以及内脏主要脏器微循环功能状态以及调节变化规律；用非常规的血液流变学测量方法，观察血液流变性特点。着重观察脑微循环的功能和结构变化对脏器乃至整个机体状态的影响。实验得出机体各脏器在１５ｄ实验中微循环功能状态的动态特性曲线及适应过程，这一变化特点与航天员飞行过程中对失重适应性反应相一致，并说明了在失重状态下心血管功能调节有明显牺牲次要器官以保护脑、心、肺等主要器官的机制，表明机体在失重条件下调控的整体性。In order to study the adaptation process during weightlessness,a series of experi-mental observations were made in rabbits confined in specially designed cages under -20°head-down position.In addition to concentration of blood and increase of permeability of capillaries,redistribution of blood flow to various organs were observed.Blood flow decreased in liver,spleen and skeletal muscleS,but increased in brain and kidneys and maintained es-sentially unchanged in the heart and lungs.It means that in order to compensate for the de-creased circulating blood volume,blood flow to the vital organs was maintained at the ex-pense of decreased flow to the organs which were comparatively unimportant during weight-lessness. Cansidering that there were concomitant increase of brai n activity and serum cAMP/cGMP ratio,t may be interpreted that the redistribution of blood flow to the various organs is an integrated process of adaptation of the organism to weightlessness,and is achieved under the participation of central control.

关 键 词：失重模拟 头低位倾斜 心血管 血液流变学 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]