79株肠球菌耐药特点分析  

Antimicrobial Resistant Characteristics of 79 Strains from Enterococcus

作　　者：张芳[1] 李玉敏[1] 崔会景[1] 

机构地区：[1]北京市通州区潞河医院,北京101149

出　　处：《中华医院感染学杂志》2006年第2期229-231,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解肠球菌对常用扰菌药物的耐药情况，指导临床合理用药。方法对我院2000-2003年各类感染标本分离出的79株肠球菌，使用微量稀释法进行药敏试验和β-内酰胺酶测试，并对结果进行分析。结果79株肠球菌中粪肠球菌58株、屎肠球菌21株；标本分离依次为尿液35．4％、外科分泌物24．1％、痰15．2％，屎肠球菌在尿液中分离率为50％，其在氨苄西林、青霉素、利福平的耐药率大于粪肠球菌；HLAR的检出率为61．9％，β-内酰胺酶检出率为6．3％，未检出VRE。结论肠球菌在尿液中最易检出，屎肠球菌在尿液中的分离率高，且耐药性强，万古霉素仍然是对肠球菌最敏感的药物，应根据分离株耐药特点选用不同的治疗方案。OBJECTIVE To realize the present resistance characteristics of enterococci to common antimicrobial agents, and to provide reference for clinical therapy. METHODS A total of 79 isolates of enteroeoeei were collected from samples during the period of 2000-2003. The broth microdilution test and β-lactamase determination were performed for each of the strains. The laboratory data were analyzed. RESULTS The rates of Enterococcus faecalis and E. faecium were 73.4%, and 26.6% of all enteroeocel isolates. The most common sites of infection were urinary tract （35. 4%）, surgical secretion （24. 1%）, and sputum （15.2%）. The rate of E. faecium approached 50% of enterococci in urinary tract. The antibiotic resistance of E. faecium was more than E. faecalis to ampicillin, penicillin, and rifampin. The ratio of HLAR enterococci and VRE to total enterococei isolates were 61.9% and 0; β-laetamase producing rate was 6.3%. CONCLUSIONS Urinary infection caused by enteroeocci is most frequent. E. faecium is found more easily in urinary tract than in the others and very resistant to antibiotics. Vancomycin shows fairly high activity against enterococci. The different regimens should be adopted for different enterococci.

关 键 词：肠球菌 耐药性 抗菌药物 

分 类 号：R378.1[医药卫生—病原生物学]