急性上呼吸道感染患儿血白介素-8与急性时相蛋白及血白细胞计数的相关性研究  

A Study on the Relationship between Interleukin-8 and Acute-phase Proteins,Blood Differential Leukocyte Count in Children with Upper Respiratory Infection

作　　者：陈啸洪[1] 夏云[2] 张佩红[1] 李华俊[1] 阮学东[1] 

机构地区：[1]绍兴文理学院第一附属医院儿科,浙江省绍兴市312000 [2]绍兴文理学院医学院

出　　处：《中国全科医学》2006年第4期284-286,共3页Chinese General Practice

摘　　要：目的研究儿童上呼吸道感染性疾病中血白介素-8(IL-8)的变化规律,并探讨其与急相蛋白(C-反应蛋白、转铁蛋白)、血白细胞分类计数的相关性。方法将287例急性上呼吸道感染患儿按照病原体的类型分为3组:病毒感染组167例、细菌感染组76例、非典型病原体感染组44例,分别抽取3组患儿的血液测定IL-8、C-反应蛋白、转铁蛋白、血白细胞分类计数,并与38例非急性上呼吸道感染的患儿(对照组)进行比较。结果急性上呼吸道感染患儿血IL-8与C-反应蛋白(CRP)、转铁蛋白(TRF)、白细胞总数、中性粒细胞、淋巴细胞间均具有相关性(P<0.001);4组患儿血白细胞计数、白细胞分类、CRP、TRF、IL-8的均值间差别均有显著性意义(P<0.001)。结论IL-8可作为儿童急性上呼吸道感染性疾病中细菌性感染与病毒性感染、非典型病原体感染的鉴别指标。Objective To observe the change rule （reaction） of blood intedeukin - 8 （ IL - 8 ） in children with upper respiratory infection, further to explore its relationship with differential leukocyte count. Methods According to the pathogen types, 287 children with upper respiratory infection were divided into three groups： viral infection group with 167 cases, bacteria group with 76 cases and atypical infection group with 44 cases. IL -8, C reactive protein, siderophilin, blood differential leukocyte count were studied in children of the three groups respectively, and compared with 38 cases with non - acute upper respiratory infection. Results In the infected group, IL -8 level in children with acute respiratory infection was related to C reactive protein, siderophilin, total white blood cells, neutrophil and lymphocyte （ P 〈0. 001 ）; There were significant differences in blood white cells count, white cells classification, CRP, TRF, IL- 8 among the four groups （ P 〈0. 001 ）. Conclusion IL -8 can be regarded as a detective marker among bacterial infection, viral infection and atypical pathogen infection in children with upper respiratory infection.

关 键 词：呼吸道感染 儿童 白介素-8 急相蛋白质类 白细胞计数 

分 类 号：R725.6[医药卫生—儿科]