全营养混合液稳定性的实验研究及临床应用  

Laboratory Study of Total Nutrient Admixture and Its Clinical Use

作　　者：蔡威[1] 陈方[1] 李敏[1] 施诚仁[1] 佘亚雄[1] 

机构地区：[1]上海第二医科大学附属新华医院小儿外科

出　　处：《中华小儿外科杂志》1996年第1期9-11,共3页Chinese Journal of Pediatric Surgery

摘　　要：为探索全营养混合液（ＴＮＡ）经周围静脉应用合理性及了解脂肪乳剂在ＴＮＡ液中的稳定性，测定了肠外营养液中各营养成分和按临床应用不同营养液配比的ｐＨ、渗透压；另用透视电镜观察脂肪乳剂在ＴＮＡ中的颗粒大小、形态变化。结果显示：ｐＨ除１０％脂肪乳剂为７．３８外，余均在５．１６～６．６７；渗透压除脂肪乳剂为等渗外，余均为高澎液。将所有营养成分按临床应用比例混合后，其ｐＨ为６．２０～６．３０，渗透压１６２４，５８～１９３４．０３ｋＰａ。脂肪乳剂混合前平均颗粒直径为０．４μｍ，脂肪乳剂加入ＴＮＡ２４小时后，平均直径０．３５μｍ，颗粒完整，但与５％氯化钙或５０％葡萄糖混合２４小时后，颗粒直径达０．９μｍ，颗粒形态异常。按一定程序配制混合营养液，临床应用１０００人次，未见不良反应。A study on the pH and osmotic pressure of various preparations and the individual components of total parenteral nutrition fluid was conducted.In addition,the diameter and the surface loooking of the fat emulsion particles were observed.The results showed:pH was 5.16-6.67 for all nutrients except for fat emulsion which was 7.38;and osmotic pressure was hypertonic for all nutrient components except for fat emulsion which was isotonic. The pH of pediatric TNA was 6.20-6.30 and osmotic pressure was 1624. 58～1934.03kPa. The average particle diameter was 0.4 μm and reduced to 0.35 μm when it was put in TNA for 24 hours,and the surface was smooth.When fat emulsion mixed with 5%CaCl2 or 50%dextrose for 24 hours,its diameter increased to 0.9 um and the surface of particles was deformed.The TNA being so mixed in certain order has been used over ont3 thousand times in clinical practice,no side effect was found.

关 键 词：全营养混合液 稳定性 胃肠外高营养 

分 类 号：R977.9[医药卫生—药品] R459.3[医药卫生—药学]