醒脑静用于慢性肺源性心脏病急性发作期的疗效观察  

Effect of Xingnaojing on patients with acute onset of chronic cor pulmonale.

作　　者：杨映娟[1] 蔡新隆 庄义先 洪小苹 

机构地区：[1]广东省普宁华侨医院内一科,515300

出　　处：《中国综合临床》2006年第3期202-204,共3页Clinical Medicine of China

摘　　要：目的评价酚妥拉明、多巴胺和醒脑静治疗慢性肺源性心脏病(肺心病)急性期的临床疗效。方法239例慢性肺心病急性发作期患者随机分为3组:Ⅰ组:给予氧疗、平喘、祛痰、抗感染、利尿、强心及糖皮质激素等常规治疗。Ⅱ组:不用利尿、强心药,加用酚妥拉明及多巴胺。Ⅲ组:在Ⅱ组治疗基础上加用醒脑静注射液静脉滴注。对各组临床疗效进行对比分析。结果总有效率:Ⅰ组59.1%,Ⅱ组89.2%,Ⅲ组100%。Ⅱ组和Ⅲ组总有效率均明显高于Ⅰ组(均为P<0.01);Ⅱ组和Ⅲ组相比差异有显著性(P<0.05)。住院病死率:Ⅰ组为20.5%,Ⅱ组为2.4%,Ⅲ组为0。Ⅱ组和Ⅲ组均低于Ⅰ组(均为P<0.01)。肺性脑病病死率:Ⅰ组为55.6%,Ⅱ组为50.0%,Ⅲ组为0。Ⅰ组、Ⅱ组与Ⅲ组比较,差异有显著性(P<0.01)。结论酚妥拉明、多巴胺及醒脑静联合用于慢性肺心病急性加重期,特别是合并肺性脑病的患者,其综合疗效明显优于长期沿用的传统疗法。Objective To evaluate the clinical effects of regitine （ RGT）, Dopaimine （DPM） and Xingnaojing （ XNJ） on patients with acute onset of chronic cor pulmonale. Methods 239 cases of acute onset of chronic cot pulmonale were randomly divided into three groups. Group Ⅰ was given routine therapy including oxygen-therapy, antispasmodics, antibiotics, andrenocortieal steroid, diuretics and earditonies, group Ⅱ were adopted RGT and DPM instead of diuretics and carditonics, group Ⅲ was added XNJ besides RGT and DPM. The clinical effects were compared among the groups. Results The overall effective rates were 59.1% in group Ⅰ ,89.2% in group Ⅱ and 100% in group m. The overall effective rates of group Ⅱ and m were significantly higher than that of group Ⅰ （P 〈0.01 for each）. There was significant difference in overall effective rates between group Ⅱ and group Ⅲ （P 〈0. 05 ）. The hospitalized mortality rates were 20.5% in group Ⅰ ,2.4% in group Ⅱ and 0 in group Ⅲ. The mortality rates of group II and group Ⅲ were lower than that of group Ⅰ （ P 〈 0.01 ）. The mortality rates of pulmonary encephalopathy were 55.6% in group Ⅰ ,50% in group Ⅱ and 0 in group m with significant difference between group Ⅰ , Ⅱ and group Ⅲ （P 〈0.01 ）. Conclusion The effect of combined Regitine,dopamine and Xingnaojing are superior to the long-lasting conventional therapy in patients with acute onset of chronic cor pulmonale, especially the patients complicated with pulmonary eneephalopathy.

关 键 词：慢性肺源性心脏病 醒脑静 肺性脑病 酚妥拉明 多巴胺 

分 类 号：R541.5[医药卫生—心血管疾病]