氯沙坦与缬沙坦对老年高血压患者血尿酸及尿α1-微球蛋白的影响  

Effect of Losartan and Valsartan on Uric Acid and α1-Microglobulin in Elderly Hypertensive Patients

作　　者：易远明[1] 

机构地区：[1]吴川市人民医院心内科,广东吴川524500

出　　处：《实用临床医学（江西）》2006年第2期8-10,共3页Practical Clinical Medicine

摘　　要：目的:探讨氯沙坦和缬沙坦对老年高血压患者的血压、血尿酸及尿α1-微球蛋白(α1-MG)的影响。方法:老年高血压患者60例,随机分为氯沙坦组和缬沙坦组,每组30例,分别服用氯沙坦50 mg/d及缬沙坦80 mg/d,若2周后血压未达到目标血压,即各增加剂量至100 mg/d和160 mg/d。于治疗前、后分别测量坐位血压以及血尿酸与尿α1-MG水平的变化。结果:两组治疗后收缩压及舒张压均较治疗前明显下降(P<0.01);缬沙坦组治疗后尿α1-MG水平较治疗前明显下降(P<0.01),血尿酸浓度无明显变化(P>0.05);氯沙坦组治疗后尿α1-MG水平及血尿酸浓度较治疗前均明显下降(P<0.01)。结论:氯沙坦和缬沙均能有效控制老年高血压患者的血压,对肾功能均有保护作用,但对于伴高尿酸血症患者应首选氯沙坦。Objective：To investigate the effect of Losartan and Valsartan on blood pressure, uric acid （UA） and α1-microglobulin（α1-MG）in elderly hypertensive patients. Methods： Sixty elderly hypertensive patients were randomly divided into Losartan group （n=30） and Valsartan group （n =30）. The sitting blood pressure, UA and α1-MG were measured before and after treatment. Results： After treatment, both systolic and diastolic blood pressures decreased significantly in two groups （P〈0. 01）; α1-MG after treatment in two groups and UA in Losartan group decreased significantly （P〈0. 01） ;and level of UA in Valsartan group was not changed after treatment （P2〉0.05）. Conclusion： Losartan and Valsartan can effectively control blood pressure of elderly hypertensive patients, and both drugs have renal function protection. Losartan should be used in elderly hypertensive patients with hyperuricacidemia.

关 键 词：高血压 老年 氯沙坦 缬沙坦 尿酸 Α1-微球蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]