降脂药物防治激素所致股骨头骨细胞损害的实验研究  

Using a lipid clearing drug to prevent osteocytes damage of the femoral head in steroid-treated rabbits

作　　者：周谋望[1] 秦建中[1] 刘志雄[1] 朱盛修[2] 

机构地区：[1]中国人民解放军空军总医院骨科,北京100036 [2]中国人民解放军总医院骨科

出　　处：《中华医学杂志》1996年第1期13-16,共4页National Medical Journal of China

摘　　要：目的 探讨激素所致股骨头缺血坏死的防治。方法 作者选用新西兰大白兔２３只，随机分为３组，激素治疗组８只；激素加氯笨丁酯（ｃｌｏｌｉｂｒａｔｅ）治疗组８只；对照组７只。结果治疗后６周发现，激素治疗组血胆固醇和甘油三酯明显增加，加用氯苯丁酯组血胆固醇和甘油三酯增加明显受到抑制，尤以甘油三酯更为明显。激素治疗组出现肝细胞脂肪变性；股骨头骨细胞内出现脂滴，并使骨细胞核受压，核固缩，甚至核消失。激素加用氯苯丁酯组肝细胞基本正常；股骨头骨细胞亦基本正常，细胞内未发现脂滴。结论通过氯苯丁酯的降血脂作用可以改善激素所致的脂质代谢紊乱，从而抑制其对股骨头骨细胞的损害，防止激素所致股骨头缺血的坏死。Objective We investigated experimentally the prevention ofsteroid-induced osteonecrosis of the femoral head . Methods Twenty-three rabbits were divided into three groups: ( Group S ) steroid treated , ( Group T. ) steroid and clofibrate treated , and controls. Serological tests ( cholesterol and triglyceride ) , histology and histochemicai studies. and electron microacopic examination were performed six weeks after treatment. Results The serum cholestelol and TG levels increased obviously in Group S. Although Group T animals also showed hyperlipidemia, their serum cholesterol and TG levels were much lower than those for Group 5. Group 5 animals demonstrated fatty degeneration of the liver. Lipid droplets were seen in the osteocytes of the femoral heads of these animals , which compressed the nucleus of the osteocytes along with nuclear pyknosis or absent nuclei. However , the constructures of liver cells and osteocytes of the femoral head were almost normal in Group T. Lipid containing ostescytes were not seen in these anamals. Conclusion These observations demonstrated that clofibrate decreased hyper- lipidaemia , modified lipid metabolism , and diminished steroid-induced damage to the osteocytes. This finding may be a guide to protect against steroid-induced osteonecrosis of the femoral head .

关 键 词：激素 股骨头坏死 缺血性坏死 降血脂药 

分 类 号：R681.8[医药卫生—骨科学] R972.6[医药卫生—外科学]