压力超负荷性心肌肥厚大鼠心肌ADM与ET变化的实验研究  

Changes of Adrenomedullin and Endothelin in Pressure Overload Rats with Myocardial Hypertrophy

作　　者：李勤学[1] 李春跃[1] 斯琴高娃[2] 

机构地区：[1]内蒙古医学院生理学教研室,内蒙古呼和浩特010059 [2]内蒙古自治区医院心内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2006年第2期103-105,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨心肌肾上腺髓质素(ADM)在大鼠压力超负荷性心肌肥厚中的病理生理意义及与内皮素(ET)的关系。方法:20只Wistar大鼠随机分为假手术组和腹主动脉部分缩窄致心肌肥厚组。6周后观察尾动脉收缩压(SBP),左心系数(左心室重/体重LVW/BW)的变化,采用放免分析法检测心肌ADM和ET水平。结果:心肌肥厚组与假手术组比较,SBP、LVW/BW分别增加161.7%和119.3%(P<0.01),心肌ADM、ET及ET/ADM值分别增加172.1%、246.1%、143.4%(P<0.01),ADM、ET、ET/ADM值与LVW/BW呈正相关,ADM与ET呈正相关。结论:在此心肌肥厚模型中心肌肾上腺髓质素升高,可能是作为心肌自分泌和/或旁分泌激素在组织局部起抗心肌肥厚的作用。心肌肥厚时ET、ADM间的动态平衡被打破,其调节紊乱可能是发病的重要原因之一。Objective：To investigate the pathophysiological role of cardiac adrenomedullin （ADM） and its relationship with endothelin （ET） in pressure overload rats with myocardial hypertrophy. Methods：20 Wistar rats were randomly divided into two groups： sham-operated group and myocardial hypertrophy group induced by partial abdominal arota constriction. The changes of systolic blood pressure （SBP） of caudal artery and left ventricular mess index （left ventricular weight versus body weight,LVW/BW） were observed after 6 weeks and the levels of myocardial ADM and ET were determined by radioimmunoassay method. Results： Compared with shame- operated group, SBP and left ventricular mess index in myocardial hypertrophy group increased by 161. 7 % and 119.3 % （P 〈 0.01）, and the levels of ADM, ET and the ratio of ET/ADM in myocardium increased by 172.1 %, 246.1% and 143.4%, respectively （P 〈 0.01 ）. There was positive correlation between ADM, ET, ET/ADM and LVW/BW,or ADM and ET. Conclusion：The increasing ADM may play a negative role in myocardial hypertrophy. The disbalance between ET and ADM occurs in myocardial hypertrophy,which may be one of important etiological factors.

关 键 词：心肌肥厚 肾上腺髓质素 内皮素 

分 类 号：R331.31[医药卫生—人体生理学]