卡维地洛对慢性心力衰竭患者QT离散度的影响  

Effect of Carvedilol on QT Dispersion in Patients with Chronic Heart Failure

作　　者：江中喜[1] 李昭骥[1] 陆东风[1] 

机构地区：[1]广州医学院第二附属医院心内科,广州510260

出　　处：《海峡药学》2006年第1期125-126,共2页Strait Pharmaceutical Journal

摘　　要：目的探讨卡维地洛对慢性心力衰竭患者QT离散度(QT d)的影响。方法60例慢性心力衰竭患者采用随机、单盲、对照的方法分为卡维地洛组和常规治疗组。4周后,观察所有慢性心力衰竭患者治疗前后QT c m ax、QT c m in及QT cd的变化。结果两组慢性心力衰竭患者治疗后QT c m ax和QT cd均较治疗前有明显减少(P<0.05)。结论慢性心力衰竭患者存在显著QT d增加,卡维地洛可显著降低慢性心力衰竭患者QT d。OBJECTIVE To explore the effect of Carvedilol on QT dispersion in patients with chronic heart failure. METHODS The collected QT dispersion（QTcd）,QTc max and QTc rain were measured in 60 patients with chronic heart failure,and the 60 cases of chronic heart failure were divided into two groups by using a randomized ,control and single blind method, Carvedilol group （n = 30）and routine treatment group （n = 30）. 4 weeks months after treatment,the above indices were measured again. RESULTS Both QTc max and QTcd were decreased significantly in two groups after 4 weeks treatment （P〈0. 05）,especially in Carvedilol group but QTc rain decreased no significantly（P〈0. 05）. CONCLUSION Significant increase in QTd occurred in patients with chronic heart failure. Carvedilol significantly decreased QTd in patients with chronic heart failure.

关 键 词：心力衰竭 卡堆地洛 QT离散度 

分 类 号：R969.4[医药卫生—药理学]