妊娠高血压综合征患者单核细胞趋化蛋白-1变化的意义  

Clinical significance of the changes of monocyte chemoattractant protein-1 in patients with pregnancy induced hypertension

作　　者：王子芬[1] 王红艳 宋海翔[3] 

机构地区：[1]山东中医药大学附属临沂市中医医院妇产科,山东临沂276002 [2]山东省临沂市兰山区第一人民医院妇产科 [3]山东中医药大学附属临沂市中医医院肾内科,山东临沂276002

出　　处：《中国医师杂志》2006年第2期185-186,共2页Journal of Chinese Physician

摘　　要：目的探讨妊娠高血压综合征(PIH)患者单核细胞趋化蛋白-1(MCP-1)变化的意义。方法用双抗体夹心ELISA法检测PIH患者96例及正常孕妇49例血、尿MCP-1的含量,并与肾功能指标进行相关性分析。结果PIH患者血MCP-1含量较正常孕妇显著升高,且随病情加重升高越显著。PIH组尿MCP-1的含量与尿β2-微球蛋白(β2-MG)、N-乙酰-β-D-葡萄糖酐酶(NAG)、白细胞介素-6(IL-6)、视黄醇结合蛋白(RBP)均呈显著的正相关,与内生肌酐清除率(Ccr)呈显著的负相关。结论检测尿MCP-1有助于了解PIH病情及肾损伤的程度。Objective To explore the clinical significance of changes of monocyte chemoattractant protein -1 （ MCP -1 ） in patients with pregnancy induced hypertension （ PIH ）. Methods The MCP-1 levels of urine and blood were measured by enzyme linked immunosorbent assay （ELISA） in 96 patients with PIH and 49 normal pregnant women. Results The MCP-1 levels in blood and urine in patients with PIH were significantly higher than those in normal pregnant women, and were associated with the severity of the disease. The urine MCP-1 level was positively correlated with the levels of β2-microglobulin （β2-MG）, N-acetyl-β-D-glucosaminidase （ NAG）, interleukin-6 （IL-6） and retinal -binding protein （ RBP）, and was negatively correlated with creatinine clearance rate （Ccr）. Conclusion The detection of MCP-1 is useful for examining the severity of PIH and the degree of renal injury.

关 键 词：高血压 妊娠性 单核细胞化学吸引蛋白质1 

分 类 号：R714.246[医药卫生—妇产科学]