参麦注射液对肢体缺血/再灌注时肺脂质过氧化损伤的防护作用  

EFFECTS OF SHENMAI INJECTION ON LIPID PEROXIDIATION IN THE LUNG FOLLOWING WITH ISCHEMIA/REPERFUSION(I/R) INJURY OF LIMB

作　　者：王艳蕾[1] 景友玲[1] 赵景霞[1] 段国贤[1] 杨秀红[1] 胡泊[1] 

机构地区：[1]华北煤炭医学院生理教研室,河北唐山063000

出　　处：《中国应用生理学杂志》2006年第1期13-15,共3页Chinese Journal of Applied Physiology

基　　金：华北煤炭医学院院级课题(3099-2020)

摘　　要：目的:探讨参麦注射液对肢体缺血/再灌注时肺脂质过氧化损伤的防护作用。方法:复制家兔缺血/再灌注(I/R)损伤模型,分别从右颈外静脉和左颈总动脉取血,代表入肺血和出肺血,观察入、出肺血及肺组织超氧化物歧化酶(SOD)、丙二醛(MDA)及参麦注射液对上述指标的影响。结果:与对照组比较,缺血再灌组松夹后4h入、出肺血及肺组织SOD活性明显降低,MDA含量增高(P<0.01);再灌前30min静脉给予参麦注射液后,SOD活性升高,而MDA含量降低(P<0.01)。相关分析显示MDA与SOD间存在明显负相关(P<0.05)。结论:缺血再灌注时伴有肺脏氧自由基代谢紊乱,参麦注射液通过清除氧自由基,对抗脂质过氧化,减轻肺损伤。Aim： To explore the effects of shenmai （chinese trnditionol medicine） injection on lipid peroxidiation in the lung following with isehemial/reperfusion（I/R） injury of limb. Methods： The models of I/R injury of limb were constructed in rabbits. Superoxide dismutase（SOD） and malondialdehyde（MDA） in into and out-flowing pulmonary blood（ IPB, OPB） and lung tissue were measured, as well as the effects of shenmai injection were observed. Results： Compared with sham group, the activity of SOD in IPB, OPB and lung tissue were decreased, and the content of MDA was increased after 4 h ischemia followed by 4 h reperfusion. SOD increased and MDA decreased significantly by icv shenmai injection 30 min before reperfusion. The correlation analysis indicated that MDA was negatively correlated with SOD . Conclusion： Oxygen free radicals metabolic confusion of lung occurres in the course of I/R, shenmai injection can alleviate lipid pero xidation, get rid of free radicals and inhibit the damage of lung.

关 键 词：参麦注射液 缺血再灌注 脂质过氧化 

分 类 号：Q563[生物学—生物化学]