肾综合征出血热患者血小板内游离钙离子浓度的变化  

Study on the platelet intracellular free calcium concentration of patients with hemorrhagic fever with renal syndrome

作　　者：赵千子[1] 刘正稳[1] 韩群英[1] 高麦仓[1] 

机构地区：[1]西安交通大学医学院第一附属医院传染科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2006年第1期39-41,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(30271176);陕西省科技攻关资助项目(2004K17-G8)

摘　　要：目的探讨肾综合征出血热(HFRS)患者血小板内游离钙离子浓度([Ca2+]i)与疾病的相关性。方法用流式细胞仪检测细胞中Fluo-3的荧光强度,对42例确诊的HFRS患者血小板内[Ca2+]i进行测定,并以30例正常人作为对照。结果检测显示,多尿期HFRS患者的[Ca2+]i显著高于正常对照组(P<0.01),而发热期、少尿期及恢复期的[Ca2+]i与对照组之间无统计学差异(P>0.05)。结论HFRS发病过程中有多种因素可以活化血小板,多尿期患者的血小板处于活化状态,而发热期和少尿期患者的血小板可能由于各种原因的功能缺陷导致其[Ca2+]i并不升高。Objective To investigate the relationship between hemorrhagic fever with renal syndrome （HFRS） and intracellular free calcium concentration （[Ca^2＋ ]i） of platelets. Methods Fluorescence of Fluo-3 was measured in platelets of 42 patients with HFRS and 30 healthy individuals as controls by flow cytometry. Results Platelet [Ca^2＋ ]i of patients with HFRS at the polyuric phase was significantly higher than that of the control group （P〈0.01）, while platelet [Ca^2＋ ]i of patients at the fever, oliguric and convalescence phases showed no significant difference from that of the control group（P〉0.05）. Conclusion Platelets from patients at the polyuric phase are highly activated, possibly in response to many factors in the progress of the disease. There is no significant difference between platelet [Ca^2＋ ]i of patients at the fever and oliguric phase and that of the control group, which is as widely accepted, possibly due to the functional deficiency of platelets during this disease.

关 键 词：肾综合征出血热 血小板 细胞内游离钙离子 

分 类 号：R373.32[医药卫生—病原生物学]