八正合剂抗感染作用及其对小鼠免疫功能的影响  

Anti-infection action of Bazheng mixture(BM) and effects of BM on immune function in mice

作　　者：刘如意[1] 任会勋[1] 吴捷[2] 董颖颖[1] 

机构地区：[1]西安交通大学医学院免疫与病原生物学系,陕西西安710061 [2]西安交通大学医学院药理学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2006年第1期49-51,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.398703304)

摘　　要：目的探讨八正合剂治疗泌尿系统感染性疾病的药理学作用及其对小鼠免疫功能的影响。方法将大肠杆菌注入小鼠膀胱后观察药物对细菌上行感染肾脏的抑制作用,同时检测其对小鼠免疫功能的影响。结果八正合剂灌胃给药可显著降低大肠杆菌上行感染肾脏的带菌剖面百分率[ED50为(11.01±1.63)g/kg,95%可信限为9.50-12.76 g/kg],显著提高小鼠巨噬细胞吞噬率和吞噬指数,对体液免疫和细胞免疫影响不大。结论八正合剂治疗泌尿系统感染性疾病的作用机制主要与其增强巨噬细胞吞噬功能、清除尿路细菌有关。Objective To explore the pharmacological action of Bazheng mixture（BM） on infections disease of urinary system and effects of BM on immune function in mice. Methods After E. coli was injected into bladder of mice, the kidneys were examined for the anti-infection action of BM on ascending infection; and the effects of BM on immune function of mice were tested. Results BM ig remarkably decreased the percentage of kedney＇s infections area caused by ascending infection of E. coli [ED50 was（11.01±1.63）g/kg and the 95% CL was 9.50-12.76g/kg] BM was also found effective in increasing the rate of carbon particle clearance and the index of carbon particle clearance, but BM had no significant effects on body fluid immunity and cell immunity in test for mice. Conclusion The mechanism of BM in treating infections disease of urinary system are mainly associated with the increasing rate of carbon particle clearance, and with bacteria clearance in urinary system.

关 键 词：八正合剂 抗感染 小鼠 免疫 

分 类 号：R285[医药卫生—中药学]