银屑病患者皮损中VEGF受体FLT-1和KDR的表达  

Expression of vascular endothelial growth factor receptors FLT-1 and KDR in patients with psoriasis vulgaris

作　　者：罗权[1] 张锡宝[1] 黄振明[1] 林玲[1] 何玉清[1] 

机构地区：[1]广州市皮肤病防治所,广州510095

出　　处：《中国麻风皮肤病杂志》2006年第2期111-113,共3页China Journal of Leprosy and Skin Diseases

基　　金：广东省医学科研立项课题资助(A2004581)

摘　　要：目的:检测VEGF受体FLT-1与KDR在寻常型银屑病皮损中的表达水平,探讨其在银屑病发病中的意义。方法:应用免疫组化SABC法,检测37例寻常型银屑病患者皮损和37例正常人皮肤组织FLT-1蛋白、KDR蛋白的表达。结果:寻常型银屑病皮损处的FLT-1蛋白和KDR蛋白的表达水平明显强于正常对照组(P<0.001);KDR的表达强度与寻常型银屑病严重程度指数PASI评分有显著正相关(r=0.93,P<0.001),且KDR的表达强度高于FLT-1的表达强度(P<0.05)。结论:VEGF的两种受体FLT-1与KDR在银屑病新生血管形成中具有重要作用,其中KDR起主要作用。通过阻断VEGF受体KDR以抗血管生成,可望为治疗银屑病提供一种新的有效方法。Objective： To investigate the levels of vascular endothelial growth factor （VEGF） receptors （FLT- 1 and KDR） of psoriatic lesions, and to explore its significance in the pathogenesis of psoriasis. Methods： The expression of FLT - 1 and KDR in 37 patients with psoriasis vulgaris and 37 normal controls were measured by immunohistochemistry technique （SABC）. Results： Tile expressions of FLT- 1 and KDR in psoriatic lesions were remarkably higher than those in normal controls （ P 〈 0.001 ）. The expression of KDR in psoriatic lesions was higher than that of FLT - 1＇ s （ P 〈 0.05 ）, and the expression of KDR in psoriatic lesions was positively correlated to PASI （ r = 0.93, P 〈 0.001 ）. Conclusion： VEGF receptors （ FLT - 1 and KDR） play an important role in the angiogenesis in psoriasis, of which KDR plays a more important role. Anti - angiogenesis by blocking the VEGF receptors may be an effective therapy in the treatment of psoriasis.

关 键 词：银屑病 血管内皮生长因子 受体 血管生成 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]