人甲状旁腺组织体外培养及高磷的影响  

Cultivation of human parathyroid tissue and effect of high phosphate in vitro

作　　者：王小兵[1] 王笑云[1] 毛慧娟[1] 曾鸣[1] 孙彬[1] 赵秀芬[1] 

机构地区：[1]南京医科大学第一临床医学院肾科

出　　处：《中华内分泌代谢杂志》2006年第1期79-80,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：RT-PCR检测人甲状旁腺有无磷钠转运体Pit-1mRNA表达;高磷、膦甲酸钠(PFA)刺激体外培养的人甲状旁腺组织,观察PTH分泌量的变化。发现甲状旁腺表达Pit-1;高磷通过作用于Pit-1促进PTH分泌,而PFA抑制其分泌。[ Summary] RT-PCR was used to identify the expression of Na/P cotransporter Pit-1 in human parathyroid tissue. The change of PTH secretion was observed in parathyroid in vitro exposed to high concentration of phosphate and phosphonoformic acid （PFA）. It was found that Pit-1 expressed in parathyroid tissue and high concentration of phosphate induced PTH secretion via Na/P cotransporter Pit-1, but PFA inhibited.

关 键 词：磷 甲状旁腺 膦甲酸钠 磷钠转运体 

分 类 号：R582.1[医药卫生—内分泌]