中药牛至单体体外抗解脲脲原体与人型支原体作用  

Effect of Oregano Monomers against Ureaplasma Urealyticum and Mycoplasma Hominis in Vitro

作　　者：严奉祥[1] 朱炳阳[1] 尹卫国[2] 潭海平[3] 迟秀玲[1] 严宇桢 温曙光[4] 李莲[3] 颜涛[1] 郭峰[1] 吴移谋[2] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001 [2]南华大学病原微生物研究所,湖南衡阳421001 [3]南华大学,湖南衡阳421001 [4]山东农业大学,山东泰安271018

出　　处：《中国皮肤性病学杂志》2006年第2期68-70,共3页The Chinese Journal of Dermatovenereology

基　　金：湖南省卫生厅基金资助项目(204062);湖南省教育厅重点基金资助项目(03A040);国家教育部重点基金资助项目(204095);国家"十五"攻关项目(02EFN214300457)

摘　　要：目的观察唇形科植物牛至(满坡香)单体抗解脲脲原体与人型支原体的作用,揭示牛至单体更广的抗病原微生物的范围,寻找新的抗解脲脲原体与人型支原体药物。方法采用直接液体培养基稀释方法,测定中药牛至单体对60株泌尿生殖道支原体的体外抗菌效应。结果迷迭香酸的半数最低抑菌浓度为1.024 mg/m l,咖啡酸的半数最低抑菌浓度为0.512 mg/m l,香荆芥酚的半数最低抑菌浓度为0.512 mg/m l,百里香酚的半数最低抑菌浓度为0.512 mg/m l。结论中药牛至单体具有较强抗血清型解脲脲原体或人型支原体的作用。Objective To determine the antibacterial effect of four monomers （ rosmarinic acid, caffeic acid, cavacrol and thymol） extracted from Origanum vulgare L. herb （oregano） on Ureaplasma urealytium （UU） and mycoplasma hominis （MH）, to discover oregano monomer wider extension against pathogeny microorganism and to find new drug against ureaplasma urealytium and mycoplasma hominis. Methods The MIC range and MICro of four Oregano monomers against 30 strains of Uu and 30 strains of Mh from patient genitourinary tract were determined using direct liquid culture medium dilution method. Results The MICro of rosmarinic acid,caffeic acid,cavacrol and thymol anti MU or Mh was 1. 024 mg/ml,0. 512 mg/ml,0.512 mg/ml and 0.512 mg/ml respectively. Conclusion The oregano monomers have all stronger anti - mycoplasma effect on arbitrary serotype of MU or Mh.

关 键 词：解脲脲原体 人型支原体 牛至单体 半数最低抑菌浓度 

分 类 号：R375[医药卫生—病原生物学] R285.5[医药卫生—基础医学]