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作 者:黎志刚[1] 曾仁山[1] 王瑞善[1] 杨捷[1] 吴江[1]
机构地区:[1]广州市第一人民医院皮肤科,广东广州510180
出 处:《中国皮肤性病学杂志》2006年第2期80-81,共2页The Chinese Journal of Dermatovenereology
基 金:2002~2003年度中华医学会皮肤性病分会皮肤科研究基金
摘 要:目的探讨白三烯B4在慢性荨麻疹发病中的意义及咪唑斯汀在治疗慢性荨麻疹中的抗炎作用。方法采用酶联免疫法测定42例慢性荨麻疹患者在咪唑斯汀治疗前后血清中白三烯B4的含量。结果患者治疗前血清白三烯B4水平较正常对照组高,差异有显著性;症状缓解后白三烯B4含量下降,与对照组间差异无显著性;咪唑斯汀治疗前后患者血清白三烯B4水平差异有显著性。结论咪唑斯汀能降低患者血清白三烯B4水平。Objective To explore the role of leukotriene B4 in the pathogenesis of chronic urticaria and the anti-inflammation activity of mizolastine in treating chronic urticaria. Methods Detected serum level of leukotriene B4 of 42 patients with chronic urticaria by enzyme immunoassay method before and after treatment with mizolastine. Results The results showed that serum level of leukotriene B4 of 42 patients with chronic urticaria was significantly higher than that of normal controls. There was statistical difference between the patient group and the controls. When the urticaria lesions disappeared or improved after treatment with mizolastine, serum level of leukotriene B4 of chronic urticaria patients decreased. There was statistical difference in the serum level of leukotriene B4 of chronic urticaria before and after treatment with mizolastine. Conclusion Mizolastine decreased the serum level of leukotriene B4 of chronic urticaria.
分 类 号:R758.24[医药卫生—皮肤病学与性病学]
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